David A Lomas
Overview
Explore the profile of David A Lomas including associated specialties, affiliations and a list of published articles.
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269
Citations
13526
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Recent Articles
11.
Tabberer M, Jones C, Kilbride S, Halpin D, Lomas D, Pascoe S, et al.
Adv Ther
. 2022 Jan;
39(3):1446.
PMID: 35060093
No abstract available.
12.
Lakshman Kumar P, Wilson A, Rocco A, Cho M, Wan E, Hobbs B, et al.
J Cachexia Sarcopenia Muscle
. 2021 Sep;
12(6):1803-1817.
PMID: 34523824
Background: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death globally. COPD patients with cachexia or weight loss have increased risk of death independent of body mass...
13.
Vass L, Fisk M, Cheriyan J, Mohan D, Forman J, Oseni A, et al.
ERJ Open Res
. 2021 Sep;
7(3).
PMID: 34476245
Rationale: COPD and smoking are characterised by pulmonary inflammation. F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) imaging may improve knowledge of pulmonary inflammation in COPD patients and aid early development...
14.
Bafadhel M, Barnes N, Bourke S, Compton C, Criner G, Dransfield M, et al.
Eur Respir J
. 2021 Aug;
58(3).
PMID: 34385263
No abstract available.
15.
Gordon C, Yardley S, Lomas D, Edwards S
Am J Bioeth
. 2021 Jul;
21(8):31-34.
PMID: 34313577
No abstract available.
16.
Ronzoni R, Ferrarotti I, DAcunto E, Balderacchi A, Ottaviani S, Lomas D, et al.
Int J Mol Sci
. 2021 Jun;
22(11).
PMID: 34073489
Alpha-1-antitrypsin (AAT) deficiency causes pulmonary disease due to decreased levels of circulating AAT and consequently unbalanced protease activity in the lungs. Deposition of specific AAT variants, such as the common...
17.
Raccosta S, Librizzi F, Jagger A, Noto R, Martorana V, Lomas D, et al.
Materials (Basel)
. 2021 Jun;
14(10).
PMID: 34063488
α1-Antitrypsin is a protease inhibitor belonging to the serpin family. Serpin polymerisation is at the core of a class of genetic conformational diseases called serpinopathies. These polymers are known to...
18.
Liddle J, Pearce A, Arico-Muendel C, Belyanskaya S, Brewster A, Brown M, et al.
Bioorg Med Chem Lett
. 2021 Mar;
41:127973.
PMID: 33753261
α1-antitrypsin deficiency is characterised by the misfolding and intracellular polymerisation of mutant α1-antitrypsin protein within the endoplasmic reticulum (ER) of hepatocytes. Small molecules that bind and stabilise Z α-antitrypsin were...
19.
Han M, Criner G, Dransfield M, Halpin D, Jones C, Kilbride S, et al.
ERJ Open Res
. 2021 Mar;
7(1).
PMID: 33718490
Introduction: Clinically important deterioration (CID) is a multicomponent measure for assessing disease worsening in chronic obstructive pulmonary disease (COPD). This analysis investigated the prognostic value of a CID event on...
20.
McKimpson W, Chen Y, Irving J, Zheng M, Weinberger J, Tan W, et al.
Dev Cell
. 2021 Mar;
56(6):747-760.e6.
PMID: 33667344
Loss of insulin-secreting pancreatic β cells through apoptosis contributes to the progression of type 2 diabetes, but underlying mechanisms remain elusive. Here, we identify a pathway in which the cell...