Edwin K Silverman
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Explore the profile of Edwin K Silverman including associated specialties, affiliations and a list of published articles.
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582
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Recent Articles
1.
Orchard P, Blackwell T, Kachuri L, Castaldi P, Cho M, Christenson S, et al.
medRxiv
. 2025 Mar;
PMID: 40034763
Most genetic variants associated with complex traits and diseases occur in non-coding genomic regions and are hypothesized to regulate gene expression. To understand the genetics underlying gene expression variability, we...
2.
Ziyatdinov A, Hobbs B, Kanaan-Izquierdo S, Moll M, Sakornsakolpat P, Shrine N, et al.
EBioMedicine
. 2025 Feb;
113:105609.
PMID: 40010152
Background: Chronic Obstructive Pulmonary Disease (COPD) has a broad spectrum of clinical characteristics. The aetiology of these differences is not well understood. The objective of this study is to assess...
3.
Vila M, Agusti A, Vestbo J, Celli B, Cosio B, Silverman E, et al.
ERJ Open Res
. 2025 Feb;
11(1).
PMID: 40008176
Background: The ECLIPSE study was a large, international, prospective, controlled, observational study that included COPD patients (Global Initiative for Chronic Obstructive Lung Disease (GOLD) grades 2-4), as well as smoking...
4.
Saferali A, Wienecke A, Xu Z, Liu T, Sheynkman G, Hersh C, et al.
Eur Respir J
. 2025 Feb;
PMID: 39978861
Background: Identification of COPD disease-causing genes is an important tool for understanding why COPD develops, who is at highest COPD risk, and how new COPD treatments can be developed. Previous...
5.
Kalra S, Hobbs B, Hunninghake G, Menon A, Putman R, Cutting C, et al.
Chest
. 2025 Feb;
PMID: 39947315
Background: Preserved ratio impaired spirometry (PRISm) findings are heterogeneous and include restrictive lung disease. Interstitial lung abnormalities (ILAs) may represent early interstitial lung disease. The relationship between PRISm findings and...
6.
Fortis S, Strand M, Bhatt S, Ten Eyck P, Wendt L, Parekh T, et al.
Am J Respir Crit Care Med
. 2025 Feb;
PMID: 39946437
Rationale: The impact of respiratory exacerbation on chronic obstructive pulmonary disease (COPD) is well established. The effects of respiratory exacerbations in people with cigarette smoking but normal spirometry are unknown....
7.
Deritei D, Inuzuka H, Castaldi P, Yun J, Xu Z, Anamika W, et al.
Hum Mol Genet
. 2025 Feb;
PMID: 39945347
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. The primary causes of COPD are environmental, including cigarette smoking; however, genetic susceptibility also contributes to COPD...
8.
Moll M, Hobbs B, Pratte K, Zhang C, Ghosh A, Bowler R, et al.
medRxiv
. 2025 Jan;
PMID: 39867385
Rationale: Individuals homozygous for the Alpha-1 Antitrypsin (AAT) Z allele (Pi*ZZ) exhibit heterogeneity in COPD risk. COPD occurrence in non-smokers with AAT deficiency (AATD) suggests inflammatory processes may contribute to...
9.
Zhang J, Hobbs B, Silverman E, Sparrow D, Ortega V, Xu H, et al.
JAMA
. 2025 Jan;
333(9):784-792.
PMID: 39841442
Importance: Chronic obstructive pulmonary disease (COPD) is often undiagnosed. Although genetic risk plays a significant role in COPD susceptibility, its utility in guiding spirometry testing and identifying undiagnosed cases is...
10.
Ryu M, Yun J, Kim K, Gentili M, Ghosh A, Sciurba F, et al.
BMC Genomics
. 2024 Dec;
25(1):1192.
PMID: 39695952
Background: Chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are debilitating diseases associated with divergent histopathological changes in the lungs. At present, due to cost and technical limitations,...