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Michael H Cho

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Articles 342
Citations 9384
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Recent Articles
1.
Choi S, Jurgens S, Xiao L, Hill M, Haggerty C, Sveinbjornsson G, et al.
Nat Genet . 2025 Mar; 57(3):548-562. PMID: 40050430
Atrial fibrillation (AF) is a prevalent and morbid abnormality of the heart rhythm with a strong genetic component. Here, we meta-analyzed genome and exome sequencing data from 36 studies that...
2.
Orchard P, Blackwell T, Kachuri L, Castaldi P, Cho M, Christenson S, et al.
medRxiv . 2025 Mar; PMID: 40034763
Most genetic variants associated with complex traits and diseases occur in non-coding genomic regions and are hypothesized to regulate gene expression. To understand the genetics underlying gene expression variability, we...
3.
Ziyatdinov A, Hobbs B, Kanaan-Izquierdo S, Moll M, Sakornsakolpat P, Shrine N, et al.
EBioMedicine . 2025 Feb; 113:105609. PMID: 40010152
Background: Chronic Obstructive Pulmonary Disease (COPD) has a broad spectrum of clinical characteristics. The aetiology of these differences is not well understood. The objective of this study is to assess...
4.
Saferali A, Wienecke A, Xu Z, Liu T, Sheynkman G, Hersh C, et al.
Eur Respir J . 2025 Feb; PMID: 39978861
Background: Identification of COPD disease-causing genes is an important tool for understanding why COPD develops, who is at highest COPD risk, and how new COPD treatments can be developed. Previous...
5.
Kalra S, Hobbs B, Hunninghake G, Menon A, Putman R, Cutting C, et al.
Chest . 2025 Feb; PMID: 39947315
Background: Preserved ratio impaired spirometry (PRISm) findings are heterogeneous and include restrictive lung disease. Interstitial lung abnormalities (ILAs) may represent early interstitial lung disease. The relationship between PRISm findings and...
6.
Hakim A, Connally N, Schnitzler G, Cho M, Jiang Z, Sunyaev S, et al.
Genes (Basel) . 2025 Jan; 16(1). PMID: 39858631
Low-density lipoprotein cholesterol (LDL-C) is a well-established risk factor for cardiovascular disease, and it plays a causal role in the development of atherosclerosis. Genome-wide association studies (GWASs) have successfully identified...
7.
Zhang J, Hobbs B, Silverman E, Sparrow D, Ortega V, Xu H, et al.
JAMA . 2025 Jan; 333(9):784-792. PMID: 39841442
Importance: Chronic obstructive pulmonary disease (COPD) is often undiagnosed. Although genetic risk plays a significant role in COPD susceptibility, its utility in guiding spirometry testing and identifying undiagnosed cases is...
8.
Jakubek Y, Ma X, Stilp A, Yu F, Bacon J, Wong J, et al.
Am J Hum Genet . 2025 Jan; 112(2):276-290. PMID: 39809269
Mosaic loss of Y (mLOY) is the most common somatic chromosomal alteration detected in human blood. The presence of mLOY is associated with altered blood cell counts and increased risk...
9.
Ryu M, Yun J, Kim K, Gentili M, Ghosh A, Sciurba F, et al.
BMC Genomics . 2024 Dec; 25(1):1192. PMID: 39695952
Background: Chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are debilitating diseases associated with divergent histopathological changes in the lungs. At present, due to cost and technical limitations,...
10.
Patchen B, Zhang J, Gaddis N, Bartz T, Chen J, Debban C, et al.
medRxiv . 2024 Dec; PMID: 39649580
Rationale: Accelerated decline in lung function contributes to the development of chronic respiratory disease. Despite evidence for a genetic component, few genetic associations with lung function decline have been identified....