David A Joy
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Explore the profile of David A Joy including associated specialties, affiliations and a list of published articles.
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11
Citations
322
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Recent Articles
1.
Chin M, Joy D, Samaddar M, Rana A, Chow J, Miyamoto T, et al.
SLAS Discov
. 2025 Jan;
31:100208.
PMID: 39778657
Mitochondria undergo dynamic morphological changes depending on cellular cues, stress, genetic factors, or disease. The structural complexity and disease-relevance of mitochondria have stimulated efforts to generate image analysis tools for...
2.
Repina N, Johnson H, Bao X, Zimmermann J, Joy D, Bi S, et al.
Development
. 2023 Jul;
150(14).
PMID: 37401411
In embryonic stem cell (ESC) models for early development, spatially and temporally varying patterns of signaling and cell types emerge spontaneously. However, mechanistic insight into this dynamic self-organization is limited...
3.
Silva A, Matthys O, Joy D, Kauss M, Natarajan V, Lai M, et al.
Cell Stem Cell
. 2021 Dec;
28(12):2137-2152.e6.
PMID: 34861147
During embryogenesis, paracrine signaling between tissues in close proximity contributes to the determination of their respective cell fate(s) and development into functional organs. Organoids are in vitro models that mimic...
4.
Libby A, Joy D, Elder N, Bulger E, Krakora M, Gaylord E, et al.
Development
. 2021 Jun;
148(12).
PMID: 34142711
Axial elongation of the neural tube is crucial during mammalian embryogenesis for anterior-posterior body axis establishment and subsequent spinal cord development, but these processes cannot be interrogated directly in humans...
5.
Joy D, Libby A, McDevitt T
Stem Cell Reports
. 2021 May;
16(5):1317-1330.
PMID: 33979602
Lineage tracing is a powerful tool in developmental biology to interrogate the evolution of tissue formation, but the dense, three-dimensional nature of tissue limits the assembly of individual cell trajectories...
6.
Perez-Bermejo J, Kang S, Rockwood S, Simoneau C, Joy D, Silva A, et al.
Sci Transl Med
. 2021 Mar;
13(590).
PMID: 33723017
Although coronavirus disease 2019 (COVID-19) causes cardiac dysfunction in up to 25% of patients, its pathogenesis remains unclear. Exposure of human induced pluripotent stem cell (iPSC)-derived heart cells to severe...
7.
Libby A, Joy D, McDevitt T
Methods Mol Biol
. 2020 Dec;
2258:105-116.
PMID: 33340357
Pluripotent stem cells (PSCs) possess the ability to self-organize into complex tissue-like structures; however, the genetic mechanisms and multicellular dynamics that direct such patterning are difficult to control. Here, we...
8.
Perez-Bermejo J, Kang S, Rockwood S, Simoneau C, Joy D, Ramadoss G, et al.
bioRxiv
. 2020 Sep;
PMID: 32935097
Although COVID-19 causes cardiac dysfunction in up to 25% of patients, its pathogenesis remains unclear. Exposure of human iPSC-derived heart cells to SARS-CoV-2 revealed productive infection and robust transcriptomic and...
9.
Single-Cell Determination of Cardiac Microtissue Structure and Function Using Light Sheet Microscopy
Turaga D, Matthys O, Hookway T, Joy D, Calvert M, McDevitt T
Tissue Eng Part C Methods
. 2020 Mar;
26(4):207-215.
PMID: 32111148
Native cardiac tissue is composed of heterogeneous cell populations that work cooperatively for proper tissue function; thus, engineered tissue models have moved toward incorporating multiple cardiac cell types in an...
10.
Libby A, Briers D, Haghighi I, Joy D, Conklin B, Belta C, et al.
Cell Syst
. 2019 Nov;
9(5):483-495.e10.
PMID: 31759947
Human pluripotent stem cells (hPSCs) have the intrinsic ability to self-organize into complex multicellular organoids that recapitulate many aspects of tissue development. However, robustly directing morphogenesis of hPSC-derived organoids requires...