Ashley R G Libby
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Explore the profile of Ashley R G Libby including associated specialties, affiliations and a list of published articles.
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9
Citations
84
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Recent Articles
1.
Libby A, Rito T, Radley A, Briscoe J
Development
. 2025 Jan;
152(3).
PMID: 39804120
Tissue development relies on the coordinated differentiation of stem cells in dynamically changing environments. The formation of the vertebrate neural tube from stem cells in the caudal lateral epiblast is...
2.
Rito T, Libby A, Demuth M, Domart M, Cornwall-Scoones J, Briscoe J
Nature
. 2024 Dec;
637(8046):673-682.
PMID: 39695233
The formation of the vertebrate body involves the coordinated production of trunk tissues from progenitors located in the posterior of the embryo. Although in vitro models using pluripotent stem cells...
3.
Bulger E, Muncie-Vasic I, Libby A, McDevitt T, Bruneau B
Development
. 2024 Feb;
151(6).
PMID: 38411343
In the nascent mesoderm, TBXT expression must be precisely regulated to ensure that cells exit the primitive streak and pattern the anterior-posterior axis, but how varying dosage informs morphogenesis is...
4.
Bulger E, Muncie-Vasic I, Libby A, McDevitt T, Bruneau B
bioRxiv
. 2023 Nov;
PMID: 37986746
In the nascent mesoderm, levels of Brachyury (TBXT) expression must be precisely regulated to ensure cells exit the primitive streak and pattern the anterior-posterior axis, but how this varying dosage...
5.
Vasic I, Libby A, Maslan A, Bulger E, Zalazar D, Krakora Compagno M, et al.
Dev Cell
. 2023 Jun;
58(16):1477-1488.e5.
PMID: 37354899
Biological patterning events that occur early in development establish proper tissue morphogenesis. Identifying the mechanisms that guide these patterning events is necessary in order to understand the molecular drivers of...
6.
Libby A, Joy D, Elder N, Bulger E, Krakora M, Gaylord E, et al.
Development
. 2021 Jun;
148(12).
PMID: 34142711
Axial elongation of the neural tube is crucial during mammalian embryogenesis for anterior-posterior body axis establishment and subsequent spinal cord development, but these processes cannot be interrogated directly in humans...
7.
Dewell T, Gjoni K, Liu A, Libby A, Moore A, So P, et al.
Stem Cell Res
. 2021 Jun;
53:102368.
PMID: 34087997
Age-related macular degeneration and genetic forms of blindness such as Best Disease and Retinitis Pigmentosa can be caused by degeneration of the Retinal Pigment Epithelium (RPE). RPE generated from patient-derived...
8.
Joy D, Libby A, McDevitt T
Stem Cell Reports
. 2021 May;
16(5):1317-1330.
PMID: 33979602
Lineage tracing is a powerful tool in developmental biology to interrogate the evolution of tissue formation, but the dense, three-dimensional nature of tissue limits the assembly of individual cell trajectories...
9.
Libby A, Joy D, McDevitt T
Methods Mol Biol
. 2020 Dec;
2258:105-116.
PMID: 33340357
Pluripotent stem cells (PSCs) possess the ability to self-organize into complex tissue-like structures; however, the genetic mechanisms and multicellular dynamics that direct such patterning are difficult to control. Here, we...
10.
Libby A, Briers D, Haghighi I, Joy D, Conklin B, Belta C, et al.
Cell Syst
. 2019 Nov;
9(5):483-495.e10.
PMID: 31759947
Human pluripotent stem cells (hPSCs) have the intrinsic ability to self-organize into complex multicellular organoids that recapitulate many aspects of tissue development. However, robustly directing morphogenesis of hPSC-derived organoids requires...