Todd C McDevitt
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Explore the profile of Todd C McDevitt including associated specialties, affiliations and a list of published articles.
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111
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4216
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Recent Articles
1.
Elder N, Majd A, Bulger E, Samuel R, Zholudeva L, McDevitt T, et al.
bioRxiv
. 2024 Dec;
PMID: 39677634
During development, early regionalization segregates lineages and directs diverse cell fates. Sometimes, however, distinct progenitors produce analogous cell types. For example, V2a neurons, are excitatory interneurons that emerge from different...
2.
Bulger E, McDevitt T, Bruneau B
Biol Open
. 2024 Mar;
13(3).
PMID: 38451093
Loss of Cdx2 in vivo leads to stunted development of the allantois, an extraembryonic mesoderm-derived structure critical for nutrient delivery and waste removal in the early embryo. Here, we investigate...
3.
Bulger E, Muncie-Vasic I, Libby A, McDevitt T, Bruneau B
Development
. 2024 Feb;
151(6).
PMID: 38411343
In the nascent mesoderm, TBXT expression must be precisely regulated to ensure that cells exit the primitive streak and pattern the anterior-posterior axis, but how varying dosage informs morphogenesis is...
4.
Bulger E, McDevitt T, Bruneau B
bioRxiv
. 2024 Feb;
PMID: 38328098
Proper regulation of gene dosage is critical for the development of the early embryo and the extraembryonic tissues that support it. Specifically, loss of leads to stunted development of the...
5.
Bulger E, Muncie-Vasic I, Libby A, McDevitt T, Bruneau B
bioRxiv
. 2023 Nov;
PMID: 37986746
In the nascent mesoderm, levels of Brachyury (TBXT) expression must be precisely regulated to ensure cells exit the primitive streak and pattern the anterior-posterior axis, but how this varying dosage...
6.
Meyers N, Ashuach T, Lyons D, Khalid M, Simoneau C, Erickson A, et al.
mBio
. 2023 Nov;
14(6):e0131823.
PMID: 37938000
The hepatitis C virus (HCV) causes liver disease, affecting millions. Even though we have effective antivirals that cure HCV, they cannot stop terminal liver disease. We used an adult stem...
7.
Vasic I, Libby A, Maslan A, Bulger E, Zalazar D, Krakora Compagno M, et al.
Dev Cell
. 2023 Jun;
58(16):1477-1488.e5.
PMID: 37354899
Biological patterning events that occur early in development establish proper tissue morphogenesis. Identifying the mechanisms that guide these patterning events is necessary in order to understand the molecular drivers of...
8.
Elder N, Fattahi F, McDevitt T, Zholudeva L
Front Cell Neurosci
. 2022 Oct;
16:962103.
PMID: 36238834
The rapidly growing field of cellular engineering is enabling scientists to more effectively create models of disease and develop specific cell types that can be used to repair damaged tissue....
9.
Cable J, Arlotta P, Parker K, Hughes A, Goodwin K, Mummery C, et al.
Ann N Y Acad Sci
. 2022 Sep;
1518(1):183-195.
PMID: 36177947
The ability to engineer complex multicellular systems has enormous potential to inform our understanding of biological processes and disease and alter the drug development process. Engineering living systems to emulate...
10.
Matthys O, McDevitt T
Methods Mol Biol
. 2022 May;
2485:39-53.
PMID: 35618897
Engineered cardiac tissue models aim to recapitulate the multicellular composition of the native myocardium by incorporating multiple tissue-relevant cell populations. Here, we describe the process of generating self-assembled cardiac microtissue...