Darren H Wong
Overview
Explore the profile of Darren H Wong including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
9
Citations
702
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Rai R, Banerjee M, Wong D, McCullagh E, Gupta A, Tripathi S, et al.
Bioorg Med Chem Lett
. 2016 Sep;
26(20):5103-5109.
PMID: 27614414
Temozolomide is a chemotherapeutic agent that is used in the treatment of glioblastoma and other malignant gliomas. It acts through DNA alkylation, but treatment is limited by its systemic toxicity...
2.
Dudek H, Wong D, Arvan R, Shah A, Wortham K, Ying B, et al.
Mol Ther
. 2013 Oct;
22(1):92-101.
PMID: 24089139
Despite progress in identifying molecular drivers of cancer, it has been difficult to translate this knowledge into new therapies, because many of the causal proteins cannot be inhibited by conventional...
3.
Mohammad K, Chen C, Balooch G, Stebbins E, McKenna C, Davis H, et al.
PLoS One
. 2009 Apr;
4(4):e5275.
PMID: 19357790
During development, growth factors and hormones cooperate to establish the unique sizes, shapes and material properties of individual bones. Among these, TGF-beta has been shown to developmentally regulate bone mass...
4.
Medicherla S, Li L, Ma J, Kapoun A, Gaspar N, Liu Y, et al.
Anticancer Res
. 2008 Jan;
27(6B):4149-57.
PMID: 18229422
Pancreatic cancer is one of the deadliest forms of cancer and effective treatment remains a clinical challenge. Transforming growth factor-beta (TGF-beta) has important roles in primary tumor progression and in...
5.
Tran T, Uhl M, Ma J, Janssen L, Sriram V, Aulwurm S, et al.
Neuro Oncol
. 2007 May;
9(3):259-70.
PMID: 17522330
Transforming growth factor-beta (TGF-beta) is a proinvasive and immunosuppressive cytokine that plays a major role in the malignant phenotype of gliomas. One novel strategy of disabling TGF-beta activity in gliomas...
6.
Gaspar N, Li L, Kapoun A, Medicherla S, Reddy M, Li G, et al.
Mol Pharmacol
. 2007 Apr;
72(1):152-61.
PMID: 17400764
Transforming growth factor beta (TGFbeta) is a pleiotropic factor that regulates cell proliferation, angiogenesis, metastasis, and immune suppression. Dysregulation of the TGFbeta pathway in tumor cells often leads to resistance...
7.
Guise T, Mohammad K, Clines G, Stebbins E, Wong D, Higgins L, et al.
Clin Cancer Res
. 2006 Oct;
12(20 Pt 2):6213s-6216s.
PMID: 17062703
Certain solid tumors metastasize to bone and cause osteolysis and abnormal new bone formation. The respective phenotypes of dysregulated bone destruction and bone formation represent two ends of a spectrum,...
8.
Uhl M, Aulwurm S, Wischhusen J, Weiler M, Ma J, Almirez R, et al.
Cancer Res
. 2004 Nov;
64(21):7954-61.
PMID: 15520202
The cytokine transforming growth factor (TGF)-beta, by virtue of its immunosuppressive and promigratory properties, has become a major target for the experimental treatment of human malignant gliomas. Here we characterize...
9.
Rydzewski R, Bryant C, Oballa R, Wesolowski G, Rodan S, Bass K, et al.
Bioorg Med Chem
. 2002 Aug;
10(10):3277-84.
PMID: 12150873
1-Cyanopyrrolidines have previously been reported to inhibit cysteinyl cathepsins (Falgueyret, J.-P. et al., J. Med. Chem. 2001, 44, 94). In order to optimize binding interactions for a given cathepsin and...