Andrew A Protter
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Explore the profile of Andrew A Protter including associated specialties, affiliations and a list of published articles.
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41
Citations
1450
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Recent Articles
1.
Shen Z, Halberg A, Fong J, Guo J, Song G, Louie B, et al.
Sci Rep
. 2022 Nov;
12(1):18811.
PMID: 36335206
COVID-19, first reported in late 2019, is an ongoing pandemic that has been causing devastation across the globe. Although there are multiple vaccines that can prevent severe symptoms, effective COVID-19...
2.
Kizilbash S, Gupta S, Chang K, Kawashima R, Parrish K, Carlson B, et al.
Mol Cancer Ther
. 2017 Sep;
16(12):2735-2746.
PMID: 28947502
Poly ADP-ribose polymerase (PARP) inhibitors, including talazoparib, potentiate temozolomide efficacy in multiple tumor types; however, talazoparib-mediated sensitization has not been evaluated in orthotopic glioblastoma (GBM) models. This study evaluates talazoparib...
3.
Ramachandran S, Jadhavar P, Singh M, Sharma A, Bagle G, Quinn K, et al.
Bioorg Med Chem Lett
. 2017 Jan;
27(4):750-754.
PMID: 28131712
The ATR pathway is a critical mediator of the replication stress response in cells. In aberrantly proliferating cancer cells, this pathway can help maintain sufficient genomic integrity for cancer cell...
4.
Rai R, Banerjee M, Wong D, McCullagh E, Gupta A, Tripathi S, et al.
Bioorg Med Chem Lett
. 2016 Sep;
26(20):5103-5109.
PMID: 27614414
Temozolomide is a chemotherapeutic agent that is used in the treatment of glioblastoma and other malignant gliomas. It acts through DNA alkylation, but treatment is limited by its systemic toxicity...
5.
Cochrane D, Bernales S, Jacobsen B, Cittelly D, Howe E, DAmato N, et al.
Breast Cancer Res
. 2014 Jan;
16(1):R7.
PMID: 24451109
Introduction: The androgen receptor (AR) is widely expressed in breast cancers and has been proposed as a therapeutic target in estrogen receptor alpha (ER) negative breast cancers that retain AR....
6.
Guerrero J, Alfaro I, Gomez F, Protter A, Bernales S
Prostate
. 2013 Jun;
73(12):1291-305.
PMID: 23765603
Background: Enzalutamide (formerly MDV3100 and available commercially as Xtandi), a novel androgen receptor (AR) signaling inhibitor, blocks the growth of castration-resistant prostate cancer (CRPC) in cellular model systems and was...
7.
Medicherla S, Ma J, Reddy M, Esikova I, Kerr I, Movius F, et al.
J Inflamm Res
. 2011 Nov;
3:9-16.
PMID: 22096353
Certain skin pathologies, including psoriasis, are thought to be immune-mediated inflammatory diseases. Available literature clearly indicates the involvement of inflammatory cells (neutrophils, T cells, and macrophages), their cytokines, and the...
8.
Medicherla S, Wadsworth S, Cullen B, Silcock D, Ma J, Mangadu R, et al.
Diabetes Metab Syndr Obes
. 2011 Mar;
2:91-100.
PMID: 21437122
In healthy tissue, a wound initiates an inflammatory response characterized by the presence of a hematoma, infiltration of inflammatory cells into the wound and, eventually, wound healing. In pathological conditions...
9.
Ma J, Medicherla S, Kerr I, Mangadu R, Protter A, Higgins L
J Asthma Allergy
. 2011 Mar;
1:31-44.
PMID: 21436983
p38 Mitogen-activated protein kinase (MAPK) plays a critical role in the activation of inflammatory cells. We investigated the anti-inflammatory effects of a p38α-selective MAPK inhibitor (SD-282) in a mouse transgenic...
10.
Giorgetti M, Gibbons J, Bernales S, Alfaro I, Drieu La Rochelle C, Cremers T, et al.
J Pharmacol Exp Ther
. 2010 Mar;
333(3):748-57.
PMID: 20194526
Dimebon (dimebolin) treatment enhances cognition in patients with Alzheimer's disease (AD) or Huntington's disease. Although Dimebon was originally thought to improve cognition and memory through inhibition of acetylcholinesterase (AChE) and...