Linda S Higgins
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Explore the profile of Linda S Higgins including associated specialties, affiliations and a list of published articles.
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35
Citations
1280
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Recent Articles
1.
Hideshima T, Podar K, Chauhan D, Ishitsuka K, Mitsiades C, Tai Y, et al.
Oncogene
. 2024 Aug;
43(40):3018.
PMID: 39209967
No abstract available.
2.
DePaoli A, Higgins L, Henry R, Mantzoros C, Dunn F
Diabetes Care
. 2014 Apr;
37(7):1918-23.
PMID: 24722496
Objective: INT131 besylate is a potent, nonthiazolidinedione, selective peroxisome proliferator-activated receptor γ (PPARγ) modulator (SPPARM) designed to improve glucose metabolism while minimizing the side effects of full PPARγ agonists. This...
3.
Medicherla S, Ma J, Reddy M, Esikova I, Kerr I, Movius F, et al.
J Inflamm Res
. 2011 Nov;
3:9-16.
PMID: 22096353
Certain skin pathologies, including psoriasis, are thought to be immune-mediated inflammatory diseases. Available literature clearly indicates the involvement of inflammatory cells (neutrophils, T cells, and macrophages), their cytokines, and the...
4.
Medicherla S, Wadsworth S, Cullen B, Silcock D, Ma J, Mangadu R, et al.
Diabetes Metab Syndr Obes
. 2011 Mar;
2:91-100.
PMID: 21437122
In healthy tissue, a wound initiates an inflammatory response characterized by the presence of a hematoma, infiltration of inflammatory cells into the wound and, eventually, wound healing. In pathological conditions...
5.
Ma J, Medicherla S, Kerr I, Mangadu R, Protter A, Higgins L
J Asthma Allergy
. 2011 Mar;
1:31-44.
PMID: 21436983
p38 Mitogen-activated protein kinase (MAPK) plays a critical role in the activation of inflammatory cells. We investigated the anti-inflammatory effects of a p38α-selective MAPK inhibitor (SD-282) in a mouse transgenic...
6.
Dunn F, Higgins L, Fredrickson J, DePaoli A
J Diabetes Complications
. 2010 Aug;
25(3):151-8.
PMID: 20739195
Objective: INT131 besylate is a potent non-thiazolidinedione selective peroxisome proliferator-activated receptor γ (PPARγ) modulator (SPPARM) designed to improve insulin sensitivity and glucose metabolism while minimizing the side effects of full...
7.
Omori K, Todorov I, Shintaku J, Rawson J, Al-Abdullah I, Higgins L, et al.
Pancreas
. 2010 Jan;
39(4):436-43.
PMID: 20084046
Objectives: We investigated whether the recovery of cultured human islets is improved through the addition of a p38alpha-selective mitogen-activated protein kinase inhibitor, SD-282, to clinically used serum-free culture medium. Methods:...
8.
Medicherla S, Reddy M, Ying J, Navas T, Li L, Nguyen A, et al.
Anticancer Res
. 2009 Feb;
28(6A):3827-33.
PMID: 19189670
Multiple myeloma (MM) is a clonal plasma cell malignancy, which is currently incurable. Therefore, new mono- or combined therapy treatment regimens in the early and advanced phases of MM are...
9.
Navas T, Zhou L, Estes M, Haghnazari E, Nguyen A, Mo Y, et al.
Leuk Lymphoma
. 2008 Oct;
49(10):1963-75.
PMID: 18949619
Myelodysplastic syndromes (MDS) are common causes of ineffective hematopoiesis and cytopenias in the elderly. Various myelosuppressive and proinflammatory cytokines have been implicated in the high rates of apoptosis and hematopoietic...
10.
Williams A, Issa R, Durham A, Leung S, Kapoun A, Medicherla S, et al.
Eur J Pharmacol
. 2008 Oct;
600(1-3):117-22.
PMID: 18926814
Ozone is a potent oxidant and causes airway hyperresponsiveness and neutrophilia. To determine the role of p38 mitogen-activated protein kinase (MAPK) activation, we studied the effect of a p38alpha inhibitor...