Daniel J Bolland
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Explore the profile of Daniel J Bolland including associated specialties, affiliations and a list of published articles.
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22
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1214
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Recent Articles
1.
Mielczarek O, Rogers C, Zhan Y, Matheson L, Stubbington M, Schoenfelder S, et al.
Cell Rep
. 2023 Sep;
42(9):113074.
PMID: 37676766
To produce a diverse antibody repertoire, immunoglobulin heavy-chain (Igh) loci undergo large-scale alterations in structure to facilitate juxtaposition and recombination of spatially separated variable (V), diversity (D), and joining (J)...
2.
Baizan-Edge A, Stubbs B, Stubbington M, Bolland D, Tabbada K, Andrews S, et al.
Cell Rep
. 2021 Jul;
36(2):109349.
PMID: 34260907
Generation of the primary antibody repertoire requires V(D)J recombination of hundreds of gene segments in the immunoglobulin heavy chain (Igh) locus. The role of interleukin-7 receptor (IL-7R) signaling in Igh...
3.
Hill D, Pierson W, Bolland D, Mkindi C, Carr E, Wang J, et al.
J Exp Med
. 2019 Jun;
216(8):1857-1873.
PMID: 31175140
The generation of protective humoral immunity after vaccination relies on the productive interaction between antigen-specific B cells and T follicular helper (Tfh) cells. Despite the central role of Tfh cells...
4.
Koohy H, Bolland D, Matheson L, Schoenfelder S, Stellato C, Dimond A, et al.
Genome Biol
. 2018 Sep;
19(1):126.
PMID: 30180872
Background: Aging is characterized by loss of function of the adaptive immune system, but the underlying causes are poorly understood. To assess the molecular effects of aging on B cell...
5.
Chovanec P, Bolland D, Matheson L, Wood A, Krueger F, Andrews S, et al.
Nat Protoc
. 2018 May;
13(6):1232-1252.
PMID: 29725123
For high-throughput sequencing and quantification of immunoglobulin repertoires, most methodologies use RNA. However, output varies enormously between recombined genes due to different promoter strengths and differential activation of lymphocyte subsets,...
6.
Matheson L, Bolland D, Chovanec P, Krueger F, Andrews S, Koohy H, et al.
Front Immunol
. 2017 Dec;
8:1550.
PMID: 29204143
V(D)J recombination is essential for the generation of diverse antigen receptor (AgR) repertoires. In B cells, immunoglobulin kappa () light chain recombination follows immunoglobulin heavy chain () recombination. We recently...
7.
Bolland D, Koohy H, Wood A, Matheson L, Krueger F, Stubbington M, et al.
Cell Rep
. 2016 Jun;
15(11):2475-87.
PMID: 27264181
Variable (V), diversity (D), and joining (J) (V(D)J) recombination is the first determinant of antigen receptor diversity. Understanding how recombination is regulated requires a comprehensive, unbiased readout of V gene...
8.
Bolland D, King M, Reik W, Corcoran A, Krueger C
J Vis Exp
. 2013 Aug;
(78).
PMID: 23978815
3D DNA FISH has become a major tool for analyzing three-dimensional organization of the nucleus, and several variations of the technique have been published. In this article we describe a...
9.
Loizou J, Sancho R, Kanu N, Bolland D, Yang F, Rada C, et al.
Cancer Cell
. 2011 May;
19(5):587-600.
PMID: 21575860
Defective V(D)J rearrangement of immunoglobulin heavy or light chain (IgH or IgL) or class switch recombination (CSR) can initiate chromosomal translocations. The DNA-damage kinase ATM is required for the suppression...
10.
Ramadani F, Bolland D, Garcon F, Emery J, Vanhaesebroeck B, Corcoran A, et al.
Sci Signal
. 2010 Aug;
3(134):ra60.
PMID: 20699475
B cell development is controlled by a series of checkpoints that ensure that the immunoglobulin (Ig)-encoding genes produce a functional B cell receptor (BCR) and antibodies. As part of this...