Daniel J Bolland
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Explore the profile of Daniel J Bolland including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Bolland D, Wood A, Corcoran A
Adv Exp Med Biol
. 2009 Sep;
650:59-72.
PMID: 19731801
V(D)J recombination in lymphocytes is the cutting and pasting together of antigen receptor genes in cis to generate the enormous variety of coding sequences required to produce diverse antigen receptor...
12.
Robbiani D, Bothmer A, Callen E, Reina-San-Martin B, Dorsett Y, Difilippantonio S, et al.
Cell
. 2008 Dec;
135(6):1028-38.
PMID: 19070574
Chromosomal translocation requires formation of paired double-strand DNA breaks (DSBs) on heterologous chromosomes. One of the most well characterized oncogenic translocations juxtaposes c-myc and the immunoglobulin heavy-chain locus (IgH) and...
13.
Zou X, Osborn M, Bolland D, Smith J, Corcos D, Hamon M, et al.
J Exp Med
. 2007 Dec;
204(13):3271-83.
PMID: 18086860
In healthy mammals, maturation of B cells expressing heavy (H) chain immunoglobulin (Ig) without light (L) chain is prevented by chaperone association of the H chain in the endoplasmic reticulum....
14.
Clapp J, Mitchell L, Bolland D, Fantes J, Corcoran A, Scotting P, et al.
Am J Hum Genet
. 2007 Aug;
81(2):264-79.
PMID: 17668377
Facioscapulohumeral muscular dystrophy (FSHD) is caused by deletions within the polymorphic DNA tandem array D4Z4. Each D4Z4 repeat unit has an open reading frame (ORF), termed "DUX4," containing two homeobox...
15.
Osborne C, Chakalova L, Mitchell J, Horton A, Wood A, Bolland D, et al.
PLoS Biol
. 2007 Jul;
5(8):e192.
PMID: 17622196
Transcription in mammalian nuclei is highly compartmentalized in RNA polymerase II-enriched nuclear foci known as transcription factories. Genes in cis and trans can share the same factory, suggesting that genes...
16.
Bolland D, Wood A, Afshar R, Featherstone K, Oltz E, Corcoran A
Mol Cell Biol
. 2007 May;
27(15):5523-33.
PMID: 17526723
V(D)J recombination is believed to be regulated by alterations in chromatin accessibility to the recombinase machinery, but the mechanisms responsible remain unclear. We previously proposed that antisense intergenic transcription, activated...
17.
Johnston C, Wood A, Bolland D, Corcoran A
J Immunol
. 2006 Mar;
176(7):4221-34.
PMID: 16547259
The mechanisms that regulate variable (V) gene selection during the development of the mouse IgH repertoire are not fully understood, due in part to the absence of the complete locus...
18.
Afshar R, Pierce S, Bolland D, Corcoran A, Oltz E
J Immunol
. 2006 Feb;
176(4):2439-47.
PMID: 16456003
The assembly of Ag receptor genes by V(D)J recombination is regulated by transcriptional promoters and enhancers which control chromatin accessibility at Ig and TCR gene segments to the RAG-1/RAG-2 recombinase...
19.
Clapp J, Bolland D, Hewitt J
Brief Funct Genomic Proteomic
. 2004 Jul;
2(3):213-23.
PMID: 15239924
The genomic basis of facioscapulohumeral muscular dystrophy (FSHD) is of considerable interest because of the unique nature of the molecular mutation, which is a deletion within a large, complex DNA...
20.
Bolland D, Wood A, Johnston C, Bunting S, Morgan G, Chakalova L, et al.
Nat Immunol
. 2004 Apr;
5(6):630-7.
PMID: 15107847
Antigen receptor genes undergo variable, diversity and joining (V(D)J) recombination, which requires ordered large-scale chromatin remodeling. Here we show that antisense transcription, both genic and intergenic, occurs extensively in the...