Steven W Wingett
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Explore the profile of Steven W Wingett including associated specialties, affiliations and a list of published articles.
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33
Citations
3666
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Recent Articles
1.
Campos-Leon K, Ferguson J, Gunther T, Wood C, Wingett S, Pekel S, et al.
PLoS Pathog
. 2025 Jan;
21(1):e1012506.
PMID: 39869645
Upon infection, human papillomavirus (HPV) manipulates host cell gene expression to create an environment that is supportive of a productive and persistent infection. The virus-induced changes to the host cell's...
2.
Bai Y, Mercade I, Elgendy R, Lambiase G, Peak-Chew S, Franco C, et al.
Comput Struct Biotechnol J
. 2025 Jan;
27:17-31.
PMID: 39760073
The secretory capacity of Chinese hamster ovary (CHO) cells remains a fundamental bottleneck in the manufacturing of protein-based therapeutics. Unconventional biological drugs with complex structures and processing requirements are particularly...
3.
Wong C, Wingett S, Qian C, Hunter M, Taliaferro J, Ross-Thriepland D, et al.
J Cell Biol
. 2024 Mar;
223(5).
PMID: 38448164
The microtubule motor dynein plays a key role in cellular organization. However, little is known about how dynein's biosynthesis, assembly, and functional diversity are orchestrated. To address this issue, we...
4.
Mielczarek O, Rogers C, Zhan Y, Matheson L, Stubbington M, Schoenfelder S, et al.
Cell Rep
. 2023 Sep;
42(9):113074.
PMID: 37676766
To produce a diverse antibody repertoire, immunoglobulin heavy-chain (Igh) loci undergo large-scale alterations in structure to facilitate juxtaposition and recombination of spatially separated variable (V), diversity (D), and joining (J)...
5.
Wong C, Wingett S, Qian C, Taliaferro J, Ross-Thriepland D, Bullock S
bioRxiv
. 2023 Mar;
PMID: 36909483
The cytoplasmic dynein-1 (dynein) motor plays a key role in cellular organisation by transporting a wide variety of cellular constituents towards the minus ends of microtubules. However, relatively little is...
6.
Pitera A, Szaruga M, Peak-Chew S, Wingett S, Bertolotti A
EMBO J
. 2022 Apr;
41(11):e109985.
PMID: 35466425
Halofuginone (HF) is a phase 2 clinical compound that inhibits the glutamyl-prolyl-tRNA synthetase (EPRS) thereby inducing the integrated stress response (ISR). Here, we report that halofuginone indeed triggers the predicted...
7.
Chauve L, Hodge F, Murdoch S, Masoudzadeh F, Mann H, Lopez-Clavijo A, et al.
PLoS Biol
. 2021 Nov;
19(11):e3001431.
PMID: 34723964
To survive elevated temperatures, ectotherms adjust the fluidity of membranes by fine-tuning lipid desaturation levels in a process previously described to be cell autonomous. We have discovered that, in Caenorhabditis...
8.
Freire-Pritchett P, Ray-Jones H, Della Rosa M, Eijsbouts C, Orchard W, Wingett S, et al.
Nat Protoc
. 2021 Aug;
16(9):4144-4176.
PMID: 34373652
Capture Hi-C is widely used to obtain high-resolution profiles of chromosomal interactions involving, at least on one end, regions of interest such as gene promoters. Signal detection in Capture Hi-C...
9.
Furlan-Magaril M, Ando-Kuri M, Arzate-Mejia R, Morf J, Cairns J, Roman-Figueroa A, et al.
Genome Biol
. 2021 Jun;
22(1):162.
PMID: 34099014
Background: Circadian gene expression is essential for organisms to adjust their physiology and anticipate daily changes in the environment. The molecular mechanisms controlling circadian gene transcription are still under investigation....
10.
Morf J, Wingett S
Methods Mol Biol
. 2020 Jul;
2161:175-194.
PMID: 32681513
RNA localization is an important regulatory layer of gene expression and cell functioning. The protocol guides through the Proximity RNA-seq method, in which RNA molecules are sequenced in their spatial,...