Peter Chovanec
Overview
Explore the profile of Peter Chovanec including associated specialties, affiliations and a list of published articles.
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19
Citations
558
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Recent Articles
1.
Chovanec P, Yin Y
Nucleic Acids Res
. 2025 Feb;
53(4).
PMID: 39997216
Single-cell combinatorial indexing (sci) methods have addressed major limitations of throughput and cost for many single-cell modalities. With the incorporation of linear amplification and three-level barcoding in our suite of...
2.
Quinodoz S, Bhat P, Chovanec P, Jachowicz J, Ollikainen N, Detmar E, et al.
Nat Protoc
. 2022 Jan;
17(1):36-75.
PMID: 35013617
A fundamental question in gene regulation is how cell-type-specific gene expression is influenced by the packaging of DNA within the nucleus of each cell. We recently developed Split-Pool Recognition of...
3.
Chovanec P, Yin Y
Methods Enzymol
. 2021 Nov;
661:183-204.
PMID: 34776212
Mitotic crossovers have the potential to cause large-scale genome rearrangements. Here, we describe high-throughput, single-cell, whole-genome sequencing methods for mapping crossovers genome-wide at scale. The methods are generalizable to various...
4.
Quinodoz S, Jachowicz J, Bhat P, Ollikainen N, Banerjee A, Goronzy I, et al.
Cell
. 2021 Nov;
184(23):5775-5790.e30.
PMID: 34739832
RNA, DNA, and protein molecules are highly organized within three-dimensional (3D) structures in the nucleus. Although RNA has been proposed to play a role in nuclear organization, exploring this has...
5.
Chovanec P, Collier A, Krueger C, Varnai C, Semprich C, Schoenfelder S, et al.
Nat Commun
. 2021 Apr;
12(1):2098.
PMID: 33828098
The transition from naive to primed pluripotency is accompanied by an extensive reorganisation of transcriptional and epigenetic programmes. However, the role of transcriptional enhancers and three-dimensional chromatin organisation in coordinating...
6.
Teng Y, Young J, Edwards B, Hayes P, Thompson L, Johnston C, et al.
N Biotechnol
. 2019 Oct;
55:65-76.
PMID: 31600579
We describe the 'Crescendo Mouse', a human V transgenic platform combining an engineered heavy chain locus with diverse human heavy chain V, D and J genes, a modified mouse Cγ1...
7.
Koohy H, Bolland D, Matheson L, Schoenfelder S, Stellato C, Dimond A, et al.
Genome Biol
. 2018 Sep;
19(1):126.
PMID: 30180872
Background: Aging is characterized by loss of function of the adaptive immune system, but the underlying causes are poorly understood. To assess the molecular effects of aging on B cell...
8.
Chovanec P, Bolland D, Matheson L, Wood A, Krueger F, Andrews S, et al.
Nat Protoc
. 2018 May;
13(6):1232-1252.
PMID: 29725123
For high-throughput sequencing and quantification of immunoglobulin repertoires, most methodologies use RNA. However, output varies enormously between recombined genes due to different promoter strengths and differential activation of lymphocyte subsets,...
9.
Matheson L, Bolland D, Chovanec P, Krueger F, Andrews S, Koohy H, et al.
Front Immunol
. 2017 Dec;
8:1550.
PMID: 29204143
V(D)J recombination is essential for the generation of diverse antigen receptor (AgR) repertoires. In B cells, immunoglobulin kappa () light chain recombination follows immunoglobulin heavy chain () recombination. We recently...
10.
Collier A, Panula S, Schell J, Chovanec P, Plaza Reyes A, Petropoulos S, et al.
Cell Stem Cell
. 2017 Mar;
20(6):874-890.e7.
PMID: 28343983
Human pluripotent stem cells (PSCs) exist in naive and primed states and provide important models to investigate the earliest stages of human development. Naive cells can be obtained through primed-to-naive...