Craig A Leach
Overview
Explore the profile of Craig A Leach including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
879
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Recent Articles
11.
Marblestone J, Kumar K, Eddins M, Leach C, Sterner D, Mattern M, et al.
J Biomol Screen
. 2010 Sep;
15(10):1220-8.
PMID: 20864734
The ubiquitin-proteasome system is central to the regulation of numerous cellular events, and dysregulation may lead to disease pathogenesis. E3 ubiquitin ligases typically function in concert with E1 and E2...
12.
Leach C, Tian X, Mattern M, Nicholson B
Methods Mol Biol
. 2008 Dec;
497:269-81.
PMID: 19107424
In this chapter we describe a novel, sensitive, homogenous high throughput reporter-based in vitro assay for SUMO protease activity developed by Progenra, Inc. A reporter construct was created by fusing...
13.
Uhrig R, She Y, Leach C, Plaxton W
J Biol Chem
. 2008 Aug;
283(44):29650-7.
PMID: 18728004
Phosphoenolpyruvate carboxylase (PEPC) is a tightly regulated enzyme situated at the core of plant C-metabolism. Although its anaplerotic role and control by allosteric effectors, reversible phosphorylation, and oligomerization have been...
14.
Nicholson B, Leach C, Goldenberg S, Francis D, Kodrasov M, Tian X, et al.
Protein Sci
. 2008 Apr;
17(6):1035-43.
PMID: 18424514
Conjugation or deconjugation of ubiquitin (Ub) or ubiquitin-like proteins (UBLs) to or from cellular proteins is a multifaceted and universal means of regulating cellular physiology, controlling the lifetime, localization, and...
15.
Leach C, Michael W
J Cell Biol
. 2005 Dec;
171(6):947-54.
PMID: 16344309
The homotrimeric DNA replication protein proliferating cell nuclear antigen (PCNA) is regulated by both ubiquitylation and sumoylation. We study the appearance and the impact of these modifications on chromosomal replication...
16.
Satinover D, Leach C, Stukenberg P, Brautigan D
Proc Natl Acad Sci U S A
. 2004 Jun;
101(23):8625-30.
PMID: 15173575
Aurora-A kinase is necessary for centrosome maturation, for assembly and maintenance of a bipolar spindle, and for proper chromosome segregation during cell division. Aurora-A is an oncogene that is overexpressed...