David E Sterner
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Explore the profile of David E Sterner including associated specialties, affiliations and a list of published articles.
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Articles
22
Citations
686
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Recent Articles
1.
Ai L, de Freitas Germano J, Huang C, Aniag M, Sawaged S, Sin J, et al.
Eur Heart J
. 2024 Nov;
46(4):380-393.
PMID: 39601359
Background And Aims: Almost 30% of survivors of myocardial infarction (MI) develop heart failure (HF), in part due to damage caused by the accumulation of dysfunctional mitochondria. Organelle quality control...
2.
Sanders B, Pokhrel S, Labbe A, Mathews I, Cooper C, Davidson R, et al.
Nat Commun
. 2023 Mar;
14(1):1733.
PMID: 36977673
Direct-acting antivirals are needed to combat coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). The papain-like protease (PLpro) domain of Nsp3 from SARS-CoV-2 is essential...
3.
Rainville C, Sterner D, Suresh K
Methods Mol Biol
. 2022 Nov;
2591:269-282.
PMID: 36350554
SARS-CoV-2 protease Nsp3 is a therapeutic target for developing anti-SARS-CoV-2 drugs. Nsp3 is a large multi-spanning membrane protein, and its characterization in vitro has been challenging. Here we describe an...
4.
Anwaar M, Adnan F, Abro A, Khan R, Rehman A, Osama M, et al.
Comput Biol Med
. 2021 Nov;
141:105049.
PMID: 34823857
The ongoing pandemic of Coronavirus Disease 2019 (COVID-19) has posed a serious threat to global public health. Drug repurposing is a time-efficient approach to finding effective drugs against SARS-CoV-2 in...
5.
Chirino L, Kumar S, Okumura M, Sterner D, Mattern M, Butt T, et al.
Eur J Immunol
. 2019 Sep;
50(1):48-55.
PMID: 31531847
TAM receptors (Tyro3, Axl, and Mer) are receptor tyrosine kinases (RTKs) that are expressed by multiple immune cells including NK cells. Although RTKs typically enhance cellular functions, TAM receptor ligation...
6.
USP7-Specific Inhibitors Target and Modify the Enzyme's Active Site via Distinct Chemical Mechanisms
Pozhidaeva A, Valles G, Wang F, Wu J, Sterner D, Nguyen P, et al.
Cell Chem Biol
. 2017 Oct;
24(12):1501-1512.e5.
PMID: 29056420
USP7 is a deubiquitinating enzyme that plays a pivotal role in multiple oncogenic pathways and therefore is a desirable target for new anti-cancer therapies. However, the lack of structural information...
7.
Wang L, Kumar S, Dahiya S, Wang F, Wu J, Newick K, et al.
EBioMedicine
. 2016 Oct;
13:99-112.
PMID: 27769803
Foxp3+ T-regulatory (Treg) cells are known to suppress protective host immune responses to a wide variety of solid tumors, but their therapeutic targeting is largely restricted to their transient depletion...
8.
Hughes S, Cox E, Bang S, Pinkelman R, Lopez-Nunez J, Saha B, et al.
J Lab Autom
. 2015 Feb;
20(6):621-35.
PMID: 25720598
A yeast artificial chromosome (YAC) containing a multigene cassette for expression of enzymes that enhance xylose utilization (xylose isomerase [XI] and xylulokinase [XKS]) was constructed and transformed into Saccharomyces cerevisiae...
9.
Marblestone J, Butt S, McKelvey D, Sterner D, Mattern M, Nicholson B, et al.
Cell Biochem Biophys
. 2013 May;
67(1):161-7.
PMID: 23695783
The ubiquitin pathway regulates diverse functions including protein localization and stability. The complexity of the pathway involving nearly 40 identified E2 conjugating enzymes and over 600 E3 ligases raises the...
10.
Mallory M, Law M, Sterner D, Berger S, Strich R
Mol Biol Cell
. 2012 Mar;
23(9):1609-17.
PMID: 22438583
Ume6p represses early meiotic gene transcription in Saccharomyces cerevisiae by recruiting the Rpd3p histone deacetylase and chromatin-remodeling proteins. Ume6p repression is relieved in a two-step destruction process mediated by the...