Jeffrey G Marblestone
Overview
Explore the profile of Jeffrey G Marblestone including associated specialties, affiliations and a list of published articles.
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8
Citations
297
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0
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Recent Articles
1.
Marblestone J, Butt S, McKelvey D, Sterner D, Mattern M, Nicholson B, et al.
Cell Biochem Biophys
. 2013 May;
67(1):161-7.
PMID: 23695783
The ubiquitin pathway regulates diverse functions including protein localization and stability. The complexity of the pathway involving nearly 40 identified E2 conjugating enzymes and over 600 E3 ligases raises the...
2.
Marblestone J, Larocque J, Mattern M, Leach C
Biochim Biophys Acta
. 2012 Jun;
1823(11):2094-7.
PMID: 22721718
The ubiquitin proteasome pathway controls the cellular degradation of ~80-90% of the proteome in a highly regulated manner. In this pathway, E3 ligases are responsible for the conjugation of ubiquitin...
3.
Eddins M, Marblestone J, Kumar K, Leach C, Sterner D, Mattern M, et al.
Cell Biochem Biophys
. 2011 Mar;
60(1-2):113-8.
PMID: 21448668
Progressive muscle wasting, also known as myopathy or muscle atrophy is a debilitating and life-threatening disorder. Myopathy is a pathological condition of many diseases including cancer, diabetes, COPD, and AIDS...
4.
Marblestone J, Kumar K, Eddins M, Leach C, Sterner D, Mattern M, et al.
J Biomol Screen
. 2010 Sep;
15(10):1220-8.
PMID: 20864734
The ubiquitin-proteasome system is central to the regulation of numerous cellular events, and dysregulation may lead to disease pathogenesis. E3 ubiquitin ligases typically function in concert with E1 and E2...
5.
Goldenberg S, Marblestone J, Mattern M, Nicholson B
Biochem Soc Trans
. 2010 Jan;
38(Pt 1):132-6.
PMID: 20074047
Dysregulation of the UPS (ubiquitin-proteasome system) has been implicated in a wide range of pathologies including cancer, neurodegeneration and viral infection. Inhibiting the proteasome has been shown to be an...
6.
Marblestone J
IDrugs
. 2009 Nov;
12(12):750-3.
PMID: 19943215
The Ubiquitin Drug Discovery & Diagnostics conference, held in Philadelphia, included topics covering new therapeutic developments in the field of ubiquitin drug research. This conference report highlights selected presentations on...
7.
Nicholson B, Marblestone J, Butt T, Mattern M
Future Oncol
. 2007 Mar;
3(2):191-9.
PMID: 17381419
Tagging proteins with mono- or poly-ubiquitin is now recognized as a multifaceted and universal means of regulating cell growth and physiology. It does so by controlling the cellular lifetime of...
8.
Marblestone J, Edavettal S, Lim Y, Lim P, Zuo X, Butt T
Protein Sci
. 2005 Dec;
15(1):182-9.
PMID: 16322573
Despite the availability of numerous gene fusion systems, recombinant protein expression in Escherichia coli remains difficult. Establishing the best fusion partner for difficult-to-express proteins remains empirical. To determine which fusion...