Craig A Leach
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Explore the profile of Craig A Leach including associated specialties, affiliations and a list of published articles.
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16
Citations
879
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Recent Articles
1.
Mittal P, Wang L, Akimova T, Leach C, Clemente J, Sender M, et al.
Cancers (Basel)
. 2020 Dec;
12(12).
PMID: 33322474
Host anti-tumor immunity can be hindered by various mechanisms present within the tumor microenvironment, including the actions of myeloid-derived suppressor cells (MDSCs). We investigated the role of the CCR2/MCP-1 pathway...
2.
Chauhan D, Tian Z, Nicholson B, Kumar K, Zhou B, Carrasco R, et al.
Cancer Cell
. 2012 Sep;
22(3):345-58.
PMID: 22975377
Bortezomib therapy has proven successful for the treatment of relapsed/refractory, relapsed, and newly diagnosed multiple myeloma (MM); however, dose-limiting toxicities and the development of resistance limit its long-term utility. Here,...
3.
Marblestone J, Larocque J, Mattern M, Leach C
Biochim Biophys Acta
. 2012 Jun;
1823(11):2094-7.
PMID: 22721718
The ubiquitin proteasome pathway controls the cellular degradation of ~80-90% of the proteome in a highly regulated manner. In this pathway, E3 ligases are responsible for the conjugation of ubiquitin...
4.
Orcutt S, Wu J, Eddins M, Leach C, Strickler J
Biochim Biophys Acta
. 2012 Jun;
1823(11):2079-86.
PMID: 22705352
As the importance of ubiquitylation in certain disease states becomes increasingly apparent, the enzymes responsible for removal of ubiquitin (Ub) from target proteins, deubiquitylases (DUBs), are becoming attractive targets for...
5.
Altun M, Kramer H, Willems L, McDermott J, Leach C, Goldenberg S, et al.
Chem Biol
. 2011 Nov;
18(11):1401-12.
PMID: 22118674
Converting lead compounds into drug candidates is a crucial step in drug development, requiring early assessment of potency, selectivity, and off-target effects. We have utilized activity-based chemical proteomics to determine...
6.
OLeary B, Fedosejevs E, Hill A, Bettridge J, Park J, Rao S, et al.
J Exp Bot
. 2011 Aug;
62(15):5485-95.
PMID: 21841182
This study employs transcript profiling together with immunoblotting and co-immunopurification to assess the tissue-specific expression, protein:protein interactions, and post-translational modifications (PTMs) of plant- and bacterial-type phosphoenolpyruvate carboxylase (PEPC) isozymes (PTPC...
7.
8.
Eddins M, Marblestone J, Kumar K, Leach C, Sterner D, Mattern M, et al.
Cell Biochem Biophys
. 2011 Mar;
60(1-2):113-8.
PMID: 21448668
Progressive muscle wasting, also known as myopathy or muscle atrophy is a debilitating and life-threatening disorder. Myopathy is a pathological condition of many diseases including cancer, diabetes, COPD, and AIDS...
9.
Lui T, Lacroix C, Ahmed S, Goldenberg S, Leach C, Daulat A, et al.
Mol Cell Biol
. 2011 Mar;
31(10):2053-65.
PMID: 21383061
Wnt proteins control multiple cell behaviors during development and tissue homeostasis. However, pathological activation of Wnt signaling is the underlying cause of various human diseases. The ubiquitin-proteasome system plays important...
10.
Loch C, Cuccherini C, Leach C, Strickler J
Mol Cell Proteomics
. 2010 Oct;
10(1):M110.002402.
PMID: 20956615
Microarray-based proteomics expanded the information potential of DNA arrays to the level of protein translation and interaction, but so far, not much beyond. Although enzymatic activity from immobilized proteins has...