Clara C Posthuma
Overview
Explore the profile of Clara C Posthuma including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
31
Citations
2334
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Lehmann K, Gorbalenya A, Snijder E, Posthuma C
Virology
. 2015 Oct;
487:68-74.
PMID: 26499043
All RNA viruses encode an RNA-dependent RNA polymerase (RdRp), which in arteriviruses is expressed as the C-terminal domain of nonstructural protein 9 (nsp9). Previously, potent primer-dependent RdRp activity has been...
12.
Lehmann K, Gulyaeva A, Zevenhoven-Dobbe J, Janssen G, Ruben M, Overkleeft H, et al.
Nucleic Acids Res
. 2015 Aug;
43(17):8416-34.
PMID: 26304538
RNA viruses encode an RNA-dependent RNA polymerase (RdRp) that catalyzes the synthesis of their RNA(s). In the case of positive-stranded RNA viruses belonging to the order Nidovirales, the RdRp resides...
13.
Peters H, Jochmans D, de Wilde A, Posthuma C, Snijder E, Neyts J, et al.
Bioorg Med Chem Lett
. 2015 Jun;
25(15):2923-6.
PMID: 26048809
A series of doubly flexible nucleoside analogues were designed based on the acyclic sugar scaffold of acyclovir and the flex-base moiety found in the fleximers. The target compounds were evaluated...
14.
Lehmann K, Hooghiemstra L, Gulyaeva A, Samborskiy D, Zevenhoven-Dobbe J, Snijder E, et al.
J Gen Virol
. 2015 Jun;
96(9):2643-2655.
PMID: 26041874
The 3'-terminal domain of the most conserved ORF1b in three of the four families of the order Nidovirales (except for the family Arteriviridae) encodes a (putative) 2'-O-methyltransferase (2'-O-MTase), known as...
15.
Lehmann K, Snijder E, Posthuma C, Gorbalenya A
Virus Res
. 2014 Dec;
202:12-32.
PMID: 25497126
Helicases are versatile NTP-dependent motor proteins of monophyletic origin that are found in all kingdoms of life. Their functions range from nucleic acid duplex unwinding to protein displacement and double-strand...
16.
Subissi L, Posthuma C, Collet A, Zevenhoven-Dobbe J, Gorbalenya A, Decroly E, et al.
Proc Natl Acad Sci U S A
. 2014 Sep;
111(37):E3900-9.
PMID: 25197083
In addition to members causing milder human infections, the Coronaviridae family includes potentially lethal zoonotic agents causing severe acute respiratory syndrome (SARS) and the recently emerged Middle East respiratory syndrome....
17.
Bouvet M, Lugari A, Posthuma C, Zevenhoven J, Bernard S, Betzi S, et al.
J Biol Chem
. 2014 Jul;
289(37):25783-96.
PMID: 25074927
The RNA-synthesizing machinery of the severe acute respiratory syndrome Coronavirus (SARS-CoV) is composed of 16 non-structural proteins (nsp1-16) encoded by ORF1a/1b. The 148-amino acid nsp10 subunit contains two zinc fingers...
18.
de Wilde A, Jochmans D, Posthuma C, Zevenhoven-Dobbe J, van Nieuwkoop S, Bestebroer T, et al.
Antimicrob Agents Chemother
. 2014 May;
58(8):4875-84.
PMID: 24841269
Coronaviruses can cause respiratory and enteric disease in a wide variety of human and animal hosts. The 2003 outbreak of severe acute respiratory syndrome (SARS) first demonstrated the potentially lethal...
19.
Gooskens J, Zevenhoven-Dobbe J, Claas E, Kroes A, Posthuma C
PLoS One
. 2014 Apr;
9(4):e92970.
PMID: 24699508
The pandemic influenza A (H1N1) 2009 virus (pH1N1) contains novel gene segments of zoonotic origin that lack virulence and antiviral resistance markers. We aimed to evaluate the applicability and accuracy...
20.
Deng Z, Lehmann K, Li X, Feng C, Wang G, Zhang Q, et al.
Nucleic Acids Res
. 2013 Dec;
42(5):3464-77.
PMID: 24369429
All positive-stranded RNA viruses with genomes>∼7 kb encode helicases, which generally are poorly characterized. The core of the nidovirus superfamily 1 helicase (HEL1) is associated with a unique N-terminal zinc-binding...