Clara C Posthuma
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Explore the profile of Clara C Posthuma including associated specialties, affiliations and a list of published articles.
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31
Citations
2334
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Recent Articles
21.
de Wilde A, Raj V, Oudshoorn D, Bestebroer T, van Nieuwkoop S, Limpens R, et al.
J Gen Virol
. 2013 Apr;
94(Pt 8):1749-1760.
PMID: 23620378
Coronavirus (CoV) infections are commonly associated with respiratory and enteric disease in humans and animals. The 2003 outbreak of severe acute respiratory syndrome (SARS) highlighted the potentially lethal consequences of...
22.
Manolaridis I, Gaudin C, Posthuma C, Zevenhoven-Dobbe J, Imbert I, Canard B, et al.
J Virol
. 2011 May;
85(14):7449-53.
PMID: 21561912
Arterivirus replicase polyproteins are cleaved into at least 13 mature nonstructural proteins (nsps), and in particular the nsp5-to-nsp8 region is subject to a complex processing cascade. The function of the...
23.
Posthuma C, van der Beek M, van der Blij-de Brouwer C, van der Heiden P, Marijt E, Spaan W, et al.
J Clin Virol
. 2011 Mar;
51(1):25-30.
PMID: 21388868
Background: Persistent infections with herpesviruses such as human cytomegalovirus (HCMV) frequently occur after solid organ or stem cell transplantation, and are due to either failure of the host to immunologically...
24.
Firth A, Zevenhoven-Dobbe J, Wills N, Go Y, Balasuriya U, Atkins J, et al.
J Gen Virol
. 2011 Feb;
92(Pt 5):1097-1106.
PMID: 21307223
The arterivirus family (order Nidovirales) of single-stranded, positive-sense RNA viruses includes porcine respiratory and reproductive syndrome virus and equine arteritis virus (EAV). Their replicative enzymes are translated from their genomic...
25.
Raaben M, Posthuma C, Verheije M, te Lintelo E, Kikkert M, Drijfhout J, et al.
J Virol
. 2010 May;
84(15):7869-79.
PMID: 20484504
The ubiquitin-proteasome system (UPS) is a key player in regulating the intracellular sorting and degradation of proteins. In this study we investigated the role of the UPS in different steps...
26.
Posthuma C, Pedersen K, Lu Z, Joosten R, Roos N, Zevenhoven-Dobbe J, et al.
J Virol
. 2008 Feb;
82(9):4480-91.
PMID: 18305048
The replication/transcription complex of the arterivirus equine arteritis virus (EAV) is associated with paired membranes and/or double-membrane vesicles (DMVs) that are thought to originate from the endoplasmic reticulum. Previously, coexpression...
27.
van den Born E, Posthuma C, Knoops K, Snijder E
J Gen Virol
. 2007 Mar;
88(Pt 4):1196-1205.
PMID: 17374763
Thus far, systems developed for heterologous gene expression from the genomes of nidoviruses (arteriviruses and coronaviruses) have relied mainly on the translation of foreign genes from subgenomic mRNAs, whose synthesis...
28.
Posthuma C, Nedialkova D, Zevenhoven-Dobbe J, Blokhuis J, Gorbalenya A, Snijder E
J Virol
. 2006 Jan;
80(4):1653-61.
PMID: 16439522
The highly conserved NendoU replicative domain of nidoviruses (arteriviruses, coronaviruses, and roniviruses) belongs to a small protein family whose cellular branch is prototyped by XendoU, a Xenopus laevis endoribonuclease involved...
29.
van den Born E, Posthuma C, Gultyaev A, Snijder E
J Virol
. 2005 Apr;
79(10):6312-24.
PMID: 15858015
Nidoviruses produce an extensive 3'-coterminal nested set of subgenomic (sg) mRNAs, which are used to express structural proteins and sometimes accessory proteins. In arteriviruses and coronaviruses, these mRNAs contain a...
30.
Seybert A, Posthuma C, van Dinten L, Snijder E, Gorbalenya A, Ziebuhr J
J Virol
. 2004 Dec;
79(2):696-704.
PMID: 15613297
Nidoviruses (Coronaviridae, Arteriviridae, and Roniviridae) encode a nonstructural protein, called nsp10 in arteriviruses and nsp13 in coronaviruses, that is comprised of a C-terminal superfamily 1 helicase domain and an N-terminal,...