Adriaan H de Wilde
Overview
Explore the profile of Adriaan H de Wilde including associated specialties, affiliations and a list of published articles.
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15
Citations
1871
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Recent Articles
1.
Solforosi L, Kuipers H, Jongeneelen M, Huber S, van der Lubbe J, Dekking L, et al.
J Exp Med
. 2021 Apr;
218(7).
PMID: 33909009
Safe and effective coronavirus disease-19 (COVID-19) vaccines are urgently needed to control the ongoing pandemic. While single-dose vaccine regimens would provide multiple advantages, two doses may improve the magnitude and...
2.
Bos R, Rutten L, van der Lubbe J, Bakkers M, Hardenberg G, Wegmann F, et al.
NPJ Vaccines
. 2020 Oct;
5:91.
PMID: 33083026
Development of effective preventative interventions against SARS-CoV-2, the etiologic agent of COVID-19 is urgently needed. The viral surface spike (S) protein of SARS-CoV-2 is a key target for prophylactic measures...
3.
Snijder E, Limpens R, de Wilde A, de Jong A, Zevenhoven-Dobbe J, Maier H, et al.
PLoS Biol
. 2020 Jun;
18(6):e3000715.
PMID: 32511245
Zoonotic coronavirus (CoV) infections, such as those responsible for the current severe acute respiratory syndrome-CoV 2 (SARS-CoV-2) pandemic, cause grave international public health concern. In infected cells, the CoV RNA-synthesizing...
4.
de Wilde A, Boomaars-van der Zanden A, de Jong A, Barcena M, Snijder E, Posthuma C
J Virol
. 2019 Jun;
93(18).
PMID: 31243130
Previously, the cyclophilin inhibitors cyclosporine (CsA) and alisporivir (ALV) were shown to inhibit the replication of diverse RNA viruses, including arteriviruses and coronaviruses, which both belong to the order In...
5.
de Wilde A, Pham U, Posthuma C, Snijder E
Virology
. 2018 Jul;
522:46-55.
PMID: 30014857
Cyclophilins (Cyps) belong to the family of peptidyl-prolyl isomerases (PPIases). The PPIase activity of most Cyps is inhibited by the immunosuppressive drug cyclosporin A and several of its non-immunosuppressive analogs,...
6.
de Wilde A, Zevenhoven-Dobbe J, Beugeling C, Chatterji U, de Jong D, Gallay P, et al.
Virology
. 2017 Dec;
517:148-156.
PMID: 29249267
Cyclophilin A (CypA) is an important host factor in the replication of a variety of RNA viruses. Also the replication of several nidoviruses was reported to depend on CypA, although...
7.
de Wilde A, Snijder E, Kikkert M, van Hemert M
Curr Top Microbiol Immunol
. 2017 Jun;
419:1-42.
PMID: 28643204
Coronaviruses are pathogens with a serious impact on human and animal health. They mostly cause enteric or respiratory disease, which can be severe and life threatening, e.g., in the case...
8.
de Wilde A, Falzarano D, Zevenhoven-Dobbe J, Beugeling C, Fett C, Martellaro C, et al.
Virus Res
. 2016 Nov;
228:7-13.
PMID: 27840112
Currently, there is no registered treatment for infections with emerging zoonotic coronaviruses like SARS- and MERS-coronavirus. We here report that in cultured cells low-micromolar concentrations of alisporivir, a non-immunosuppressive cyclosporin...
9.
Peters H, Jochmans D, de Wilde A, Posthuma C, Snijder E, Neyts J, et al.
Bioorg Med Chem Lett
. 2015 Jun;
25(15):2923-6.
PMID: 26048809
A series of doubly flexible nucleoside analogues were designed based on the acyclic sugar scaffold of acyclovir and the flex-base moiety found in the fleximers. The target compounds were evaluated...
10.
de Wilde A, Wannee K, Scholte F, Goeman J, Ten Dijke P, Snijder E, et al.
J Virol
. 2015 Jun;
89(16):8318-33.
PMID: 26041291
Unlabelled: To identify host factors relevant for severe acute respiratory syndrome-coronavirus (SARS-CoV) replication, we performed a small interfering RNA (siRNA) library screen targeting the human kinome. Protein kinases are key...