Claire E Witherel
Overview
Explore the profile of Claire E Witherel including associated specialties, affiliations and a list of published articles.
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10
Citations
684
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Recent Articles
1.
Yin B, Ni J, Witherel C, Yang M, Burdick J, Wen C, et al.
Theranostics
. 2022 Jan;
12(1):207-231.
PMID: 34987642
Osteoarthritis (OA) is a prevalent chronic whole-joint disease characterized by low-grade systemic inflammation, degeneration of joint-related tissues such as articular cartilage, and alteration of bone structures that can eventually lead...
2.
Galarraga J, Locke R, Witherel C, Stoeckl B, Castilho M, Mauck R, et al.
Biofabrication
. 2021 Nov;
14(1).
PMID: 34788748
Hydrogels are of interest in cartilage tissue engineering due to their ability to support the encapsulation and chondrogenesis of mesenchymal stromal cells (MSCs). However, features such as hydrogel crosslink density,...
3.
Witherel C, Sao K, Brisson B, Han B, Volk S, Petrie R, et al.
Biomaterials
. 2021 Jan;
269:120667.
PMID: 33450585
Aberrant extracellular matrix (ECM) assembly surrounding implanted biomaterials is the hallmark of the foreign body response, in which implants become encapsulated in thick fibrous tissue that prevents their proper function....
4.
Witherel C, Gurevich D, Collin J, Martin P, Spiller K
ACS Biomater Sci Eng
. 2021 Jan;
4(4):1233-1240.
PMID: 33418656
Host-biomaterial interactions are critical determinants of the success or failure of an implant. However, detailed understanding of this process is limited due to a lack of dynamic tools for in...
5.
Witherel C, Abebayehu D, Barker T, Spiller K
Adv Healthc Mater
. 2019 Jan;
8(4):e1801451.
PMID: 30658015
Biomaterial-mediated inflammation and fibrosis remain a prominent challenge in designing materials to support tissue repair and regeneration. Despite the many biomaterial technologies that have been designed to evade or suppress...
6.
Witherel C, Graney P, Spiller K
Methods Mol Biol
. 2018 Apr;
1758:161-176.
PMID: 29679330
Tissue engineering and regenerative medicine, facilitated by biomaterial-based therapies, hold promise for the repair, replacement, or regeneration of damaged tissue. The success or failure of all implanted biomaterials, ranging from...
7.
Witherel C, Yu T, Concannon M, Dampier W, Spiller K
Cell Mol Bioeng
. 2017 Dec;
10(5):451-462.
PMID: 29225709
Introduction: Chronic wounds remain a major clinical challenge. Human cryopreserved viable amniotic membrane (hCVAM) is among the most successful therapies, but the mechanisms of action remain loosely defined. Because proper...
8.
Witherel C, Graney P, Freytes D, Weingarten M, Spiller K
Wound Repair Regen
. 2016 Feb;
24(3):514-24.
PMID: 26874797
Chronic wounds remain a major burden to the global healthcare system. Myriad wound matrices are commercially available but their mechanisms of action are poorly understood. Recent studies have shown that...
9.
Spiller K, Wrona E, Romero-Torres S, Pallotta I, Graney P, Witherel C, et al.
Exp Cell Res
. 2015 Oct;
347(1):1-13.
PMID: 26500109
The mechanisms by which macrophages control the inflammatory response, wound healing, biomaterial-interactions, and tissue regeneration appear to be related to their activation/differentiation states. Studies of macrophage behavior in vitro can...
10.
Spiller K, Nassiri S, Witherel C, Anfang R, Ng J, Nakazawa K, et al.
Biomaterials
. 2014 Dec;
37:194-207.
PMID: 25453950
In normal tissue repair, macrophages exhibit a pro-inflammatory phenotype (M1) at early stages and a pro-healing phenotype (M2) at later stages. We have previously shown that M1 macrophages initiate angiogenesis...