Kara L Spiller
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Explore the profile of Kara L Spiller including associated specialties, affiliations and a list of published articles.
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67
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2270
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Recent Articles
1.
Whitaker R, Sung S, Tylek T, Risser G, OBrien E, Chua P, et al.
NPJ Regen Med
. 2025 Feb;
10(1):9.
PMID: 39939310
We took a systems approach to the analysis of macrophage phenotype in regenerative and fibrotic volumetric muscle loss outcomes in mice together with analysis of systemic inflammation and of other...
2.
DeCostanza L, Grogan G, Bruce A, Peachey C, Clark E, Atkins K, et al.
Acta Biomater
. 2024 Nov;
191:260-275.
PMID: 39522628
Acellular Dermal Matrix (ADM) provides mechanical and soft tissue support in implant-based breast reconstruction, and has shown to modulate the healing response. However, skin flap necrosis, edema, and previous radiation...
3.
Hernaez-Estrada B, Steele L, Spiller K
Wound Repair Regen
. 2024 Oct;
32(6):992-1007.
PMID: 39359182
Bioengineered allogeneic cellularised constructs (BACC) exert pro-healing effects in burn wounds and skew macrophage phenotype towards a predominately reparative phenotype. However, whether BACC can modulate the phenotype of dysregulated macrophages,...
4.
Whitaker R, Sung S, Tylek T, Risser G, OBrien E, Chua P, et al.
bioRxiv
. 2024 Sep;
PMID: 39253495
We took a systems approach to the analysis of macrophage phenotype in regenerative and fibrotic volumetric muscle loss outcomes in mice together with analysis of systemic inflammation and of other...
5.
Sousa A, Cunha A, Santos-Coquillat A, Hernaez Estrada B, Spiller K, Barao M, et al.
Adv Mater
. 2024 May;
36(30):e2405367.
PMID: 38739450
Therapeutic cells are usually administered as living agents, despite the risks of undesired cell migration and acquisition of unpredictable phenotypes. Additionally, most cell-based therapies rely on the administration of single...
6.
Tylek T, Wong J, Vaughan A, Spiller K
Biomaterials
. 2024 Mar;
308:122545.
PMID: 38547831
Macrophages are key modulators of all inflammatory diseases and essential for their resolution, making macrophage cell therapy a promising strategy for regenerative medicine. However, since macrophages change rapidly in response...
7.
Steele L, Hernaez Estrada B, Spiller K
Adv Healthc Mater
. 2024 Mar;
14(5):e2303044.
PMID: 38507713
The mechanisms behind the pro-healing effects of multicellular, bioengineered allogeneic cellularized constructs (BACC) are not known. Macrophages are key regulators of every phase of the wound healing process and the...
8.
Sung S, Steele L, Risser G, Spiller K
Adv Drug Deliv Rev
. 2023 Jul;
199:114979.
PMID: 37394101
Although most tissue types are capable of some form of self-repair and regeneration, injuries that are larger than a critical threshold or those occurring in the setting of certain diseases...
9.
Boerman O, Abedin Z, DiMaria-Ghalili R, Weingarten M, Neidrauer M, Lewin P, et al.
Front Med (Lausanne)
. 2023 Apr;
10:1144182.
PMID: 37064037
Introduction: Low-frequency, low-intensity ultrasound has been previously shown to promote healing of chronic wounds in humans, but mechanisms behind these effects are poorly understood. The purpose of this study was...
10.
Risser G, Machour M, Hernaez-Estrada B, Li D, Levenberg S, Spiller K
Biomaterials
. 2023 Mar;
296:122095.
PMID: 36989737
Macrophages are major regulators of angiogenesis in response to injury, but the mechanisms behind their diverse and phenotypically specific functions are still poorly understood. In particular, the effects of interleukin-4...