Donald O Freytes
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Explore the profile of Donald O Freytes including associated specialties, affiliations and a list of published articles.
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55
Citations
2473
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Recent Articles
1.
Ayus-Martinez S, Meza-Morales W, Jimenez-Osorio J, Buendia-Otero M, Lopez L, Cunci L, et al.
Extracell Vesicle
. 2025 Jan;
4.
PMID: 39866746
Matrix-bound vesicles (MBVs), an integral part of the extracellular matrix (ECM), are emerging as pivotal factors in ECM-driven molecular signaling. This study is the first to report the isolation of...
2.
Meza-Morales W, Jimenez-Socha M, Freytes D, Mora C
Results Probl Cell Differ
. 2024 Oct;
74:55-87.
PMID: 39406901
Macrophages are critical to the immune response, serving multiple essential roles in maintaining tissue homeostasis and providing immune protection. These cells also interact with and influence the extracellular matrix (ECM)...
3.
Doherty E, Krohn G, Warren E, Patton A, Whitworth C, Rathod M, et al.
Adv Healthc Mater
. 2024 Mar;
13(19):e2400192.
PMID: 38518808
Microphysiological and organ-on-chip platforms seek to address critical gaps in human disease models and drug development that underlie poor rates of clinical success for novel interventions. While the fabrication technology...
4.
Nalband D, Sarker P, Khan S, Freytes D
J Biomed Mater Res B Appl Biomater
. 2023 Sep;
112(1):e35321.
PMID: 37715569
Reactive oxygen species (ROS) play a critical and important role during wound healing but excess ROS at the wound site can lead to cellular damage and sub-optimal healing. Minimizing oxidative...
5.
Gracioso Martins A, Snider D, Popowski K, Schuchard K, Tenorio M, Akunuri S, et al.
J Control Release
. 2023 Jun;
359:287-301.
PMID: 37301267
Although nebulizers have been developed for delivery of small molecules in human patients, no tunable device has been purpose-built for targeted delivery of modern large molecule and temperature-sensitive therapeutics to...
6.
Biehl A, Colmon R, Timofeeva A, Gracioso Martins A, Dion G, Peters K, et al.
Bioengineering (Basel)
. 2023 May;
10(5).
PMID: 37237672
The vocal folds (VFs) are constantly exposed to mechanical stimulation leading to changes in biomechanical properties, structure, and composition. The development of long-term strategies for VF treatment depends on the...
7.
Biehl A, Gracioso Martins A, Davis Z, Sze D, Collins L, Mora-Navarro C, et al.
Biomater Sci
. 2022 Dec;
11(2):641-654.
PMID: 36504129
The goal of tissue decellularization is to efficiently remove unwanted cellular components, such as DNA and cellular debris, while retaining the complex structural and molecular milieu within the extracellular matrix...
8.
Sarker P, Nalband D, Freytes D, Rojas O, Khan S
Biomacromolecules
. 2022 Oct;
23(11):4696-4708.
PMID: 36198084
Injectable collagen-based hydrogels offer great promise for tissue engineering and regeneration, but their use is limited by poor mechanical strength. Herein, we incorporate tannic acid (TA) to tailor the rheology...
9.
Detwiler A, Polkoff K, Gaffney L, Freytes D, Piedrahita J
Tissue Eng Part A
. 2022 Aug;
28(19-20):833-844.
PMID: 35925753
Current cellular hydrogel-based skin grafts composed of human dermal fibroblasts and a hydrogel scaffold tend to minimize contraction of full-thickness skin wounds and support skin regeneration. However, there has been...
10.
Mora-Navarro C, Garcia M, Sarker P, Ozpinar E, Enders J, Khan S, et al.
Biomed Mater
. 2021 Nov;
17(1).
PMID: 34731852
Extracellular matrix (ECM) is a complex structure composed of bioactive molecules representative of the local tissue microenvironment. Decellularized ECM biomaterials harness these biomolecules for regenerative medicine applications. One potential therapeutic...