Christopher V Nicchitta
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Explore the profile of Christopher V Nicchitta including associated specialties, affiliations and a list of published articles.
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71
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2891
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Recent Articles
11.
Hish A, Nagy G, Fang C, Kelley L, Nicchitta C, Dzirasa K, et al.
CBE Life Sci Educ
. 2019 Oct;
18(4):ar51.
PMID: 31622166
Although doctoral students in the biomedical sciences have been recognized as a population at particular risk for mental health problems such as burnout and depression, little research has been conducted...
12.
Nagy G, Fang C, Hish A, Kelly L, Nicchitta C, Dzirasa K, et al.
CBE Life Sci Educ
. 2019 Jun;
18(2):ar27.
PMID: 31150319
Although burnout and mental health problems may adversely impact quality of scientific research, academic productivity, and attrition in biomedical doctoral training programs, very little research has been done on this...
13.
Hoffman A, Chen Q, Zheng T, Nicchitta C
J Biol Chem
. 2019 Apr;
294(22):8942-8958.
PMID: 31004035
The endoplasmic reticulum (ER) is a nexus for mRNA localization and translation, and recent studies have demonstrated that ER-bound ribosomes also play a transcriptome-wide role in regulating proteome composition. The...
14.
Hsu J, Reid D, Hoffman A, Sarkar D, Nicchitta C
RNA
. 2018 Feb;
24(5):688-703.
PMID: 29438049
Astrocyte elevated gene-1 (AEG-1), an oncogene whose overexpression promotes tumor cell proliferation, angiogenesis, invasion, and enhanced chemoresistance, is thought to function primarily as a scaffolding protein, regulating PI3K/Akt and Wnt/β-catenin...
15.
Reid D, Campos R, Child J, Zheng T, Chan K, Bradrick S, et al.
J Virol
. 2018 Jan;
92(7).
PMID: 29321322
A primary question in dengue virus (DENV) biology is the molecular strategy for recruitment of host cell protein synthesis machinery. Here, we combined cell fractionation, ribosome profiling, and transcriptome sequencing...
16.
Reid D, Tay A, Sundaram J, Lee I, Chen Q, George S, et al.
Mol Cell Biol
. 2016 May;
36(13):1868-80.
PMID: 27161320
Phosphorylation of eukaryotic initiation factor 2α (eIF2α) controls transcriptome-wide changes in mRNA translation in stressed cells. While phosphorylated eIF2α (P-eIF2α) attenuates global protein synthesis, mRNAs encoding stress proteins are more...
17.
Reid D, Shenolikar S, Nicchitta C
Methods
. 2015 Jul;
91:69-74.
PMID: 26164698
The development and application of ribosome profiling has markedly advanced our understanding of ribosomes and mRNA translation. The experimental approach, which relies on deep sequencing of ribosome-protected mRNA fragments generated...
18.
Reid D, Nicchitta C
Science
. 2015 Jun;
348(6240):1217.
PMID: 26068841
Jan et al. (Research Articles, 7 November 2014, p. 716) propose that ribosomes translating secretome messenger RNAs (mRNAs) traffic from the cytosol to the endoplasmic reticulum (ER) upon emergence of...
19.
Reid D, Nicchitta C
Nat Rev Mol Cell Biol
. 2015 Mar;
16(4):221-31.
PMID: 25735911
Pioneering electron microscopy studies defined two primary populations of ribosomes in eukaryotic cells: one freely dispersed through the cytoplasm and the other bound to the surface of the endoplasmic reticulum...
20.
Brooks S, Wall A, Golzio C, Reid D, Kondyles A, Willer J, et al.
Genetics
. 2014 Oct;
198(2):723-33.
PMID: 25316788
Neurodevelopmental defects in humans represent a clinically heterogeneous group of disorders. Here, we report the genetic and functional dissection of a multigenerational pedigree with an X-linked syndromic disorder hallmarked by...