Sujatha Jagannathan
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Explore the profile of Sujatha Jagannathan including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
593
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Recent Articles
1.
Cortazar M, Jagannathan S
Methods Mol Biol
. 2024 Nov;
2863:397-417.
PMID: 39535722
Generating nonessential gene knockouts using CRISPR/Cas9 technology is becoming increasingly common in biological research. In a typical workflow, the Cas9 endonuclease is used to induce a DNA double-strand break that...
2.
Kolakada D, Campbell A, Galvis L, Li Z, Lore M, Jagannathan S
Nucleic Acids Res
. 2024 Feb;
52(6):e34.
PMID: 38375914
Nonsense-mediated mRNA decay (NMD) is a network of pathways that degrades transcripts that undergo premature translation termination. In mammals, NMD can be divided into the exon junction complex (EJC)-enhanced and...
3.
Kolakada D, Fu R, Biziaev N, Shuvalov A, Lore M, Campbell A, et al.
bioRxiv
. 2024 Jan;
PMID: 38260612
Nonsense variants underlie many genetic diseases. The phenotypic impact of nonsense variants is determined by nonsense-mediated mRNA decay (NMD), which degrades transcripts with premature termination codons (PTCs). Despite its clinical...
4.
Kolakada D, Campbell A, Galvis L, Li Z, Lore M, Jagannathan S
bioRxiv
. 2023 Nov;
PMID: 38014198
Nonsense-mediated mRNA decay (NMD) is a network of pathways that degrades transcripts that undergo premature translation termination. In mammals, NMD can be divided into the exon junction complex (EJC)-enhanced and...
5.
Campbell A, Arjomand J, King O, Tawil R, Jagannathan S
J Neuromuscul Dis
. 2023 Oct;
10(6):1031-1040.
PMID: 37899061
Background: Facioscapulohumeral muscular dystrophy (FSHD) is a progressive myopathy caused by misexpression of the double homeobox 4 (DUX4) embryonic transcription factor in skeletal muscle. Identifying quantitative and minimally invasive FSHD...
6.
Hamm D, Paatela E, Bennett S, Wong C, Campbell A, Wladyka C, et al.
PLoS Biol
. 2023 Sep;
21(9):e3002317.
PMID: 37747887
Translational control is critical for cell fate transitions during development, lineage specification, and tumorigenesis. Here, we show that the transcription factor double homeobox protein 4 (DUX4), and its previously characterized...
7.
Campbell A, Dyle M, Albanese R, Matheny T, Sudheendran K, Cortazar M, et al.
Cell Rep
. 2023 Jun;
42(6):112642.
PMID: 37314931
Nonsense-mediated RNA decay (NMD) degrades transcripts carrying premature termination codons. NMD is thought to prevent the synthesis of toxic truncated proteins. However, whether loss of NMD results in widespread production...
8.
Munoz O, Lore M, Jagannathan S
Biochem Soc Trans
. 2023 May;
51(3):1121-1129.
PMID: 37145092
Nonsense-mediated RNA decay (NMD) plays a dual role as an RNA surveillance mechanism against aberrant transcripts containing premature termination codons and as a gene regulatory mechanism for normal physiological transcripts....
9.
Sherlock M, Galvis L, Vicens Q, Kieft J, Jagannathan S
RNA
. 2023 Apr;
29(7):865-884.
PMID: 37024263
The gene expression pathway from DNA sequence to functional protein is not as straightforward as simple depictions of the central dogma might suggest. Each step is highly regulated, with complex...
10.
The evolution of DUX4 gene regulation and its implication for facioscapulohumeral muscular dystrophy
Jagannathan S
Biochim Biophys Acta Mol Basis Dis
. 2022 Feb;
1868(5):166367.
PMID: 35158020
Double homeobox 4 (DUX4) is an early embryonic transcription factor whose expression in the skeletal muscle causes facioscapulohumeral muscular dystrophy (FSHD). Despite decades of research, our knowledge of FSHD and...