Samuel B Stephens
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Explore the profile of Samuel B Stephens including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
593
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Recent Articles
1.
Blom S, Behan-Bush R, Ankrum J, Yang L, Stephens S
bioRxiv
. 2025 Feb;
PMID: 39975379
Type 1 diabetes (T1D) is caused by the selective autoimmune ablation of pancreatic β-cells. Emerging evidence reveals β-cell secretory dysfunction arises early in T1D development and may contribute to diseases...
2.
Montaser H, Leppanen S, Vahakangas E, Back N, Grace A, Eurola S, et al.
Diabetes
. 2024 Oct;
PMID: 39441964
Immediate early response 3 interacting-protein 1 (IER3IP1) is an endoplasmic reticulum resident protein, highly expressed in pancreatic cells and the developing brain cortex. Homozygous mutations in IER3IP1 have been found...
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The NR4A2/VGF pathway fuels inflammation-induced neurodegeneration via promoting neuronal glycolysis
Woo M, Bal L, Winschel I, Manca E, Walkenhorst M, Sevgili B, et al.
J Clin Invest
. 2024 Aug;
134(16).
PMID: 39145444
A disturbed balance between excitation and inhibition (E/I balance) is increasingly recognized as a key driver of neurodegeneration in multiple sclerosis (MS), a chronic inflammatory disease of the central nervous...
5.
Rohli K, Stubbe N, Walker E, Pearson G, Soleimanpour S, Stephens S
JCI Insight
. 2024 Jun;
9(15).
PMID: 38935435
ER stress and proinsulin misfolding are heralded as contributing factors to β cell dysfunction in type 2 diabetes, yet how ER function becomes compromised is not well understood. Recent data...
6.
Boyer C, Blom S, Machado A, Rohli K, Maxson M, Stephens S
Am J Physiol Endocrinol Metab
. 2024 Jan;
326(3):E245-E257.
PMID: 38265287
Delayed Golgi export of proinsulin has recently been identified as an underlying mechanism leading to insulin granule loss and β-cell secretory defects in type 2 diabetes (T2D). Because acidification of...
7.
Sue N, Thai L, Saito A, Boyer C, Fordham A, Yan C, et al.
Mol Metab
. 2023 Nov;
79:101845.
PMID: 38013154
Objective: Although individual steps have been characterized, there is little understanding of the overall process whereby glucose co-ordinates the biosynthesis of insulin with its export out of the endoplasmic reticulum...
8.
Brennecke B, Yang U, Liu S, Ilerisoy F, Ilerisoy B, Joglekar A, et al.
Front Endocrinol (Lausanne)
. 2023 Jun;
14:1187216.
PMID: 37305047
Introduction: With technical advances, confocal and super-resolution microscopy have become powerful tools to dissect cellular pathophysiology. Cell attachment to glass surfaces compatible with advanced imaging is critical prerequisite but remains...
9.
Boyer C, Bauchle C, Zhang J, Wang Y, Stephens S
Sci Rep
. 2023 Mar;
13(1):5218.
PMID: 36997560
The pancreatic islet β-cell's preference for release of newly synthesized insulin requires careful coordination of insulin exocytosis with sufficient insulin granule production to ensure that insulin stores exceed peripheral demands...
10.
Rohli K, Boyer C, Bearrows S, Moyer M, Elison W, Bauchle C, et al.
Function (Oxf)
. 2022 Nov;
3(6):zqac051.
PMID: 36325514
Defects in the pancreatic β-cell's secretion system are well-described in type 2 diabetes (T2D) and include impaired proinsulin processing and a deficit in mature insulin-containing secretory granules; however, the cellular...