Christopher V Nicchitta
Overview
Explore the profile of Christopher V Nicchitta including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
71
Citations
2891
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Kristofich J, Nicchitta C
Bio Protoc
. 2024 Aug;
14(14):e5236.
PMID: 39100593
The critical roles of RNA-binding proteins (RBPs) in all aspects of RNA biology fostered the development of methods utilizing ultraviolet (UV) crosslinking and method-specific RNA enrichment steps for proteome-wide identification...
2.
Fellmann F, Saunders C, ODonohue M, Reid D, McFadden K, Montel-Lehry N, et al.
JCI Insight
. 2024 Aug;
9(17).
PMID: 39088281
Diamond-Blackfan anemia syndrome (DBA) is a ribosomopathy associated with loss-of-function variants in more than 20 ribosomal protein (RP) genes. Here, we report the genetic, functional, and biochemical dissection of 2...
3.
Kristofich J, Nicchitta C
RNA
. 2024 Feb;
30(6):644-661.
PMID: 38423626
UV-crosslinking has proven to be an invaluable tool for the identification of RNA-protein interactomes. The paucity of methods for distinguishing background from bona fide RNA-protein interactions, however, makes attribution of...
4.
Kristofich J, Nicchitta C
Nat Commun
. 2023 Sep;
14(1):5868.
PMID: 37735163
Recent efforts towards the comprehensive identification of RNA-bound proteomes have revealed a large, surprisingly diverse family of candidate RNA-binding proteins (RBPs). Quantitative metrics for characterization and validation of protein-RNA interactions...
5.
Ang H, Sutiman N, Deng X, Liu A, Cerda-Smith C, Hutchinson H, et al.
Proc Natl Acad Sci U S A
. 2023 Sep;
120(38):e2221448120.
PMID: 37695916
Evidence has long suggested that epidermal growth factor receptor (EGFR) may play a prominent role in triple-negative breast cancer (TNBC) pathogenesis, but clinical trials of EGFR inhibitors have yielded disappointing...
6.
Child J, Hofler A, Chen Q, Yang B, Kristofich J, Zheng T, et al.
RNA
. 2023 Aug;
29(11):1703-1724.
PMID: 37643813
Signal recognition particle (SRP) pathway function in protein translocation across the endoplasmic reticulum (ER) is well established; its role in RNA localization to the ER remains, however, unclear. In current...
7.
Nicchitta C
Semin Cell Dev Biol
. 2022 Oct;
156:160-166.
PMID: 36202692
Stress granules (SGs), structurally dynamic, optically resolvable, macromolecular assemblies of mRNAs, RNA binding proteins (RBPs), translation factors, ribosomal subunits, as well as other interacting proteins, assemble in response to cell...
8.
McKernan C, Khatri A, Hannigan M, Child J, Chen Q, Mayro B, et al.
Cell Rep
. 2022 Aug;
40(9):111268.
PMID: 36044842
Patients with human epidermal growth factor receptor 2-positive (HER2+/ERBB2) breast cancer often present with brain metastasis. HER2-targeted therapies have not been successful to treat brain metastases in part due to...
9.
Child J, Chen Q, Reid D, Jagannathan S, Nicchitta C
RNA
. 2021 Jul;
27(10):1241-1256.
PMID: 34244458
Stress granules (SGs) are membraneless organelles composed of mRNAs and RNA binding proteins which undergo assembly in response to stress-induced inactivation of translation initiation. In general, SG recruitment is limited...
10.
Hannigan M, Hoffman A, Thompson J, Zheng T, Nicchitta C
Mol Cell Proteomics
. 2020 Aug;
19(11):1826-1849.
PMID: 32788342
Protein synthesis on the endoplasmic reticulum (ER) requires the dynamic coordination of numerous cellular components. Together, resident ER membrane proteins, cytoplasmic translation factors, and both integral membrane and cytosolic RNA-binding...