Christopher G Langendorf
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Explore the profile of Christopher G Langendorf including associated specialties, affiliations and a list of published articles.
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31
Citations
619
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Recent Articles
1.
Smiles W, Ovens A, Yu D, Ling N, Poblete Goycoolea A, Morrison K, et al.
NPJ Metab Health Dis
. 2025 Mar;
3(1):8.
PMID: 40052110
The nutrient-sensitive protein kinases AMPK and mTORC1 form a fundamental negative feedback loop that governs cell growth and proliferation. mTORC1 phosphorylates α2-S345 in the AMPK αβγ heterotrimer to suppress its...
2.
Wells C, Liang Y, Pulliam T, Lin C, Awad D, Eduful B, et al.
Cells
. 2023 Jan;
12(2).
PMID: 36672221
The serine/threonine protein kinase calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) plays critical roles in a range of biological processes. Despite its importance, only a handful of inhibitors of CAMKK2 have...
3.
Rosdah A, Abbott B, Langendorf C, Deng Y, Truong J, Waddell H, et al.
Sci Rep
. 2022 Dec;
12(1):21531.
PMID: 36513726
Mitochondrial dynamin-related protein 1 (Drp1) is a large GTPase regulator of mitochondrial dynamics and is known to play an important role in numerous pathophysiological processes. Despite being the most widely...
4.
Ovens A, Gee Y, Ling N, Yu D, Hardee J, Chung J, et al.
Biochem J
. 2022 May;
479(11):1181-1204.
PMID: 35552369
The AMP-activated protein kinase (AMPK) αβγ heterotrimer is a primary cellular energy sensor and central regulator of energy homeostasis. Activating skeletal muscle AMPK with small molecule drugs improves glucose uptake...
5.
Eduful B, OByrne S, Temme L, Asquith C, Liang Y, Picado A, et al.
J Med Chem
. 2021 Jul;
64(15):10849-10877.
PMID: 34264658
CAMKK2 is a serine/threonine kinase and an activator of AMPK whose dysregulation is linked with multiple diseases. Unfortunately, STO-609, the tool inhibitor commonly used to probe CAMKK2 signaling, has limitations....
6.
Ovens A, Scott J, Langendorf C, Kemp B, Oakhill J, Smiles W
Int J Mol Sci
. 2021 Jan;
22(3).
PMID: 33513781
Physical exercise elicits physiological metabolic perturbations such as energetic and oxidative stress; however, a diverse range of cellular processes are stimulated in response to combat these challenges and maintain cellular...
7.
Langendorf C, OBrien M, Ngoei K, McAloon L, Dhagat U, Hoque A, et al.
J Biol Chem
. 2020 Sep;
295(48):16239-16250.
PMID: 32913128
The calcium-calmodulin-dependent protein kinase kinase-2 (CaMKK2) is a key regulator of cellular and whole-body energy metabolism. It is known to be activated by increases in intracellular Ca, but the mechanisms...
8.
Spengler K, Zibrova D, Woods A, Langendorf C, Scott J, Carling D, et al.
Biochem J
. 2020 Sep;
477(17):3453-3469.
PMID: 32869834
Activation of AMP-activated protein kinase (AMPK) in endothelial cells by vascular endothelial growth factor (VEGF) via the Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) represents a pro-angiogenic pathway, whose regulation and...
9.
Pinkosky S, Scott J, Desjardins E, Smith B, Day E, Ford R, et al.
Nat Metab
. 2020 Jul;
2(9):873-881.
PMID: 32719536
Long-chain fatty acids (LCFAs) play important roles in cellular energy metabolism, acting as both an important energy source and signalling molecules. LCFA-CoA esters promote their own oxidation by acting as...
10.
Rosdah A, Smiles W, Oakhill J, Scott J, Langendorf C, Delbridge L, et al.
Pharmacol Ther
. 2020 Jun;
213:107594.
PMID: 32473962
Mitochondria are dynamic organelles constantly undergoing fusion and fission. A concerted balance between the process of mitochondrial fusion and fission is required to maintain cellular health under different physiological conditions....