Christopher G Langendorf
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Explore the profile of Christopher G Langendorf including associated specialties, affiliations and a list of published articles.
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31
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619
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Recent Articles
11.
Ling N, Langendorf C, Hoque A, Galic S, Loh K, Kemp B, et al.
Bipolar Disord
. 2020 Mar;
22(8):841-848.
PMID: 32216002
Objectives: Loss-of-function mutations in the gene encoding the calcium-calmodulin (Ca -CaM)-dependent protein kinase kinase-2 (CaMKK2) enzyme are linked to bipolar disorder. Recently, a de novo arginine to cysteine (R311C) mutation...
12.
Ling N, Kaczmarek A, Hoque A, Davie E, Ngoei K, Morrison K, et al.
Nat Metab
. 2020 Jan;
2(1):41-49.
PMID: 31993556
Central to cellular metabolism and cell proliferation are highly conserved signalling pathways controlled by mammalian target of rapamycin (mTOR) and AMP-activated protein kinase (AMPK), dysregulation of which are implicated in...
13.
OByrne S, Scott J, Pilotte J, Santiago A, Langendorf C, Oakhill J, et al.
Molecules
. 2020 Jan;
25(2).
PMID: 31941153
The calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) activates CAMK1, CAMK4, AMPK, and AKT, leading to numerous physiological responses. The deregulation of CAMKK2 is linked to several diseases, suggesting the utility...
14.
Asquith C, Godoi P, Counago R, Laitinen T, Scott J, Langendorf C, et al.
Molecules
. 2018 May;
23(5).
PMID: 29783765
We demonstrate for the first time that 4-1,2,6-thiadiazin-4-one (TDZ) can function as a chemotype for the design of ATP-competitive kinase inhibitors. Using insights from a co-crystal structure of a 3,5-bis(arylamino)-4-1,2,6-thiadiazin-4-one...
15.
Dite T, Langendorf C, Hoque A, Galic S, Rebello R, Ovens A, et al.
J Biol Chem
. 2018 Apr;
293(23):8874-8885.
PMID: 29695504
Inhibition of the metabolic regulator AMP-activated protein kinase (AMPK) is increasingly being investigated for its therapeutic potential in diseases where AMPK hyperactivity results in poor prognoses, as in established cancers...
16.
Ngoei K, Langendorf C, Ling N, Hoque A, Varghese S, Camerino M, et al.
Cell Chem Biol
. 2018 Apr;
25(6):728-737.e9.
PMID: 29657085
The AMP-activated protein kinase (AMPK) αβγ heterotrimer regulates cellular energy homeostasis with tissue-specific isoform distribution. Small-molecule activation of skeletal muscle α2β2 AMPK complexes may prove a valuable treatment strategy for...
17.
Langendorf C, Oakhill J, Kemp B
Methods Mol Biol
. 2018 Feb;
1732:15-27.
PMID: 29480466
Here, we describe the crystallization protocol for AMPK, including protein production and purification. AMPK can be readily crystallized in the presence of PEG to give diffracting crystals to a resolution...
18.
Dite T, Ling N, Scott J, Hoque A, Galic S, Parker B, et al.
Nat Commun
. 2017 Sep;
8(1):571.
PMID: 28924239
AMP-activated protein kinase (AMPK) is a metabolic stress-sensing enzyme responsible for maintaining cellular energy homeostasis. Activation of AMPK by salicylate and the thienopyridone A-769662 is critically dependent on phosphorylation of...
19.
Langendorf C, Scott J, Kemp B
Cell Chem Biol
. 2017 Jul;
24(7):775-777.
PMID: 28732195
Protein kinase inhibitors have become increasingly important therapeutic drugs for the treatment of human diseases; however, resistance and off-target effects can limit their use. In this issue of Cell Chemical...
20.
OBrien M, Oakhill J, Ling N, Langendorf C, Hoque A, Dite T, et al.
Sci Rep
. 2017 Feb;
7:43264.
PMID: 28230171
The Ca-calmodulin dependent protein kinase kinase-2 (CaMKK2) is a key regulator of neuronal function and whole-body energy metabolism. Elevated CaMKK2 activity is strongly associated with prostate and hepatic cancers, whereas...