Jonathan S Oakhill
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Explore the profile of Jonathan S Oakhill including associated specialties, affiliations and a list of published articles.
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79
Citations
2232
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Recent Articles
1.
Smiles W, Ovens A, Yu D, Ling N, Poblete Goycoolea A, Morrison K, et al.
NPJ Metab Health Dis
. 2025 Mar;
3(1):8.
PMID: 40052110
The nutrient-sensitive protein kinases AMPK and mTORC1 form a fundamental negative feedback loop that governs cell growth and proliferation. mTORC1 phosphorylates α2-S345 in the AMPK αβγ heterotrimer to suppress its...
2.
Matos A, Ovens A, Jakobsen E, Iglesias-Gato D, Bech J, Friis S, et al.
Cells
. 2025 Feb;
14(4).
PMID: 39996767
Aspirin has consistently shown preventive effects in some solid cancers, notably colorectal cancer. However, the precise molecular mechanisms underlying this positive effect have remained elusive. In this study, we used...
3.
Ovens A, Yu D, Dite T, Kemp B, Oakhill J
Methods Mol Biol
. 2025 Feb;
2882:3-14.
PMID: 39992502
Adenine nucleotides (AXPs, also referred to as adenosines or adenylates) are a group of organic molecules including adenosine 5'- mono-, di-, and tri-phosphate (AMP, ADP, and ATP, respectively) that, combined,...
4.
Gillespie A, Mehdorn A, Lim T, Wang T, Mooney B, Ovens A, et al.
NPJ Metab Health Dis
. 2025 Feb;
3(1):5.
PMID: 39991135
Metformin is a well-tolerated drug frequently prescribed for managing type 2 diabetes. Extended metformin use has been linked to a significant decrease in cancer incidence across both diabetic and non-diabetic...
5.
Kang J, Gallucci S, Pan J, Oakhill J, Sanij E
Front Cell Dev Biol
. 2024 Nov;
12:1449543.
PMID: 39544365
STK11 (serine-threonine kinase 11), also known as LKB1 (liver kinase B1) is a highly conserved master kinase that regulates cellular metabolism and polarity through a complex signaling network involving AMPK...
6.
Cater R, Ryan R, Oakhill J, Czabotar P, Murphy J, Call M
Structure
. 2024 Nov;
32(11):1847-1849.
PMID: 39515301
Since 1976, the Lorne Proteins Conference has been a key gathering for protein scientists, combining cutting-edge research with community engagement in a picturesque corner of the world. Renowned for its...
7.
Kaiser J, Risteska A, Muller A, Sun H, Lei B, Nay K, et al.
Biol Psychiatry
. 2024 Oct;
97(5):439-449.
PMID: 39442785
Although the precise underlying cause(s) of autism spectrum disorder remain unclear, more than 1000 rare genetic variations are associated with the condition. For many people living with profound autism, this...
8.
Smiles W, Ovens A, Oakhill J, Kofler B
Mol Metab
. 2024 Oct;
90():102042.
PMID: 39362600
Background: AMP-activated protein kinase (AMPK) is an evolutionarily conserved regulator of energy metabolism. AMPK is sensitive to acute perturbations to cellular energy status and leverages fundamental bioenergetic pathways to maintain...
9.
Smiles W, Ovens A, Kemp B, Galic S, Petersen J, Oakhill J
Essays Biochem
. 2024 Jul;
68(3):321-336.
PMID: 38994736
Metabolic homeostasis and the ability to link energy supply to demand are essential requirements for all living cells to grow and proliferate. Key to metabolic homeostasis in all eukaryotes are...
10.
Katerelos M, Gleich K, Harley G, Loh K, Oakhill J, Kemp B, et al.
Biomed Pharmacother
. 2024 May;
175:116730.
PMID: 38749175
Acute kidney injury (AKI) disrupts energy metabolism. Targeting metabolism through AMP-activated protein kinase (AMPK) may alleviate AKI. ATX-304, a pan-AMPK activator, was evaluated in C57Bl/6 mice and tubular epithelial cell...