Christian J Grimme
Overview
Explore the profile of Christian J Grimme including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
79
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Recent Articles
1.
Lembke H, Espinasse A, Hanson M, Grimme C, Tan Z, Reineke T, et al.
ACS Chem Biol
. 2023 Sep;
18(9):2063-2072.
PMID: 37671702
The bacterial cell envelope provides a protective barrier that is challenging for small molecules and biomolecules to cross. Given the anionic nature of both Gram-positive and Gram-negative bacterial cell envelopes,...
2.
Hanson M, Grimme C, Kreofsky N, Panda S, Reineke T
Bioconjug Chem
. 2023 Jul;
34(8):1418-1428.
PMID: 37437196
Nucleic acid-based medicines and vaccines are becoming an important part of our therapeutic toolbox. One key genetic medicine is antisense oligonucleotides (ASOs), which are short single-stranded nucleic acids that downregulate...
3.
Grimme C, Hanson M, Reineke T
Bioconjug Chem
. 2023 Jun;
34(7):1244-1257.
PMID: 37384839
Herein, we examine the ASO-mediated gene silencing efficiency of pH-responsive micelles, by incorporating 2-(diisopropylamino)ethyl methacrylate (DIP) into the micelle core and comparing physical and biological properties with non-pH-responsive micelles. Additionally,...
4.
Hanson M, Grimme C, Santa Chalarca C, Reineke T
Bioconjug Chem
. 2023 Jan;
34(2):454-455.
PMID: 36630311
No abstract available.
5.
Hanson M, Grimme C, Santa Chalarca C, Reineke T
Bioconjug Chem
. 2022 Oct;
33(11):2121-2131.
PMID: 36265078
Antisense oligonucleotides (ASOs) are an important emerging therapeutic; however, they struggle to enter cells without a delivery vehicle, such as a cationic polymer. To understand the role of polymer architecture...
6.
Grimme C, Hanson M, Corcoran L, Reineke T
Biomacromolecules
. 2022 Jul;
23(8):3257-3271.
PMID: 35862267
Herein, we examine the complexation and biological delivery of a short single-stranded antisense oligonucleotide (ASO) payload with four polymer derivatives that form two architectural variants (polyplexes and micelleplexes): a homopolymer...
7.
Kumar R, Santa Chalarca C, Bockman M, Van Bruggen C, Grimme C, Dalal R, et al.
Chem Rev
. 2021 May;
121(18):11527-11652.
PMID: 33939409
The advent of genome editing has transformed the therapeutic landscape for several debilitating diseases, and the clinical outlook for gene therapeutics has never been more promising. The therapeutic potential of...