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Carlo Ballatore

Explore the profile of Carlo Ballatore including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 69
Citations 2607
Followers 0
Related Specialties
Chemistry
Biochemistry
Neurology
Top 10 Co-Authors
Kurt R Brunden
Amos B Smith 3rd
Virginia M-Y Lee
John Q Trojanowski
Yuemang Yao
Michael J James
Killian Oukoloff
Andrea Brancale
Karol R Francisco
Anne-Sophie Cornec
Published In
Bioorg Med Chem Lett
J Med Chem
ChemMedChem
J Biol Chem
Eur J Med Chem
Affiliations
Soon will be listed here.
Recent Articles
1.
Kaempferia parviflora extract and its methoxyflavones as potential anti-Alzheimer assessing in vitro, integrated computational approach, and in vivo impact on behaviour in scopolamine-induced amnesic mice
Takomthong P, Waiwut P, Yenjai C, Wangboonskul J, Plekratoke K, Arsito P, et al.
PLoS One . 2025 Mar; 20(3):e0316888. PMID: 40063637
Alzheimer's disease (AD), a growing global challenge, lacks effective preventive and therapeutic strategies. This study explored the promising potential of the Kaempferia parviflora (KP) and its methoxyflavones (MFs) against the...
2.
Clickable Probes for Pathogen Proteasomes: Synthesis and Applications
Liu L, Lucero B, Manriquez-Rodriguez C, Francisco K, Teixeira T, Yohannan D, et al.
ACS Omega . 2024 Aug; 9(32):34829-34840. PMID: 39157084
The 20S proteasome is a multimeric protease complex that is essential for proteostasis in the cell. Small molecule proteasome inhibitors are approved drugs for various cancers and are advancing clinically...
3.
A small-molecule microtubule-stabilizing agent safely reduces Aβ plaque and tau pathology in transgenic mouse models of Alzheimer's disease
Yao Y, Muench M, Alle T, Zhang B, Lucero B, Perez-Tremble R, et al.
Alzheimers Dement . 2024 Jun; 20(7):4540-4558. PMID: 38884283
Introduction: Intraneuronal inclusions composed of tau protein are found in Alzheimer's disease (AD) and other tauopathies. Tau normally binds microtubules (MTs), and its disengagement from MTs and misfolding in AD...
4.
Design, Synthesis, and Evaluation of An Anti-trypanosomal [1,2,4]Triazolo[1,5-a]pyrimidine Probe for Photoaffinity Labeling Studies
Lucero B, Francisco K, Varricchio C, Liu L, Yao Y, Brancale A, et al.
ChemMedChem . 2024 Jan; 19(8):e202300656. PMID: 38277231
Studies have shown that depending on the substitution pattern, microtubule (MT)-targeting 1,2,4-triazolo[1,5-a]pyrimidines (TPDs) can produce different cellular responses in mammalian cells that may be due to these compounds interacting with...
5.
Targeted Reversible Covalent Modification of a Noncatalytic Lysine of the Krev Interaction Trapped 1 Protein Enables Site-Directed Screening for Protein-Protein Interaction Inhibitors
Francisco K, Bruystens J, Varricchio C, McCurdy S, Wu J, Lopez-Ramirez M, et al.
ACS Pharmacol Transl Sci . 2023 Nov; 6(11):1651-1658. PMID: 37974623
The covalent reversible modification of proteins is a validated strategy for the development of probes and candidate therapeutics. However, the covalent reversible targeting of noncatalytic lysines is particularly challenging. Herein,...
6.
A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injury
Zhao X, Zeng W, Xu H, Sun Z, Hu Y, Peng B, et al.
Sci Transl Med . 2023 Sep; 15(713):eabo6889. PMID: 37703352
Tau pathogenesis is a hallmark of many neurodegenerative diseases, including Alzheimer's disease (AD). Although the events leading to initial tau misfolding and subsequent tau spreading in patient brains are largely...
7.
Structure-Activity Relationships, Tolerability and Efficacy of Microtubule-Active 1,2,4-Triazolo[1,5-a]pyrimidines as Potential Candidates to Treat Human African Trypanosomiasis
Monti L, Liu L, Varricchio C, Lucero B, Alle T, Yang W, et al.
ChemMedChem . 2023 Jul; 18(20):e202300193. PMID: 37429821
Tubulin and microtubules (MTs) are potential protein targets to treat parasitic infections and our previous studies have shown that the triazolopyrimidine (TPD) class of MT-active compounds hold promise as antitrypanosomal...
8.
Structure-property relationships of fluorinated carboxylic acid bioisosteres
Alle T, Joyasawal S, Oukoloff K, Long K, Owyang Z, Francisco K, et al.
Bioorg Med Chem Lett . 2023 Jun; 91:129363. PMID: 37295616
Fluorinated alcohols and phenols are potentially useful as bioisosteres of the carboxylic acid functional group. To enable a direct comparison of the properties of fluorinated carboxylic acid surrogates with those...
9.
Protein-protein interactions: developing small-molecule inhibitors/stabilizers through covalent strategies
Lucero B, Francisco K, Liu L, Caffrey C, Ballatore C
Trends Pharmacol Sci . 2023 Jun; 44(7):474-488. PMID: 37263826
The development of small-molecule inhibitors or stabilizers of selected protein-protein interactions (PPIs) of interest holds considerable promise for the development of research tools as well as candidate therapeutics. In this...
10.
Structure-Activity Relationships, Tolerability and Efficacy of Microtubule-Active 1,2,4-Triazolo[1,5- ]pyrimidines as Potential Candidates to Treat Human African Trypanosomiasis
Monti L, Liu L, Varricchio C, Lucero B, Alle T, Yang W, et al.
bioRxiv . 2023 Mar; PMID: 36945407
Tubulin and microtubules (MTs) are potential protein targets to treat parasitic infections and our previous studies have shown that the triazolopyrimidine (TPD) class of MT- active compounds hold promise as...