Brigham H Mecham
Overview
Explore the profile of Brigham H Mecham including associated specialties, affiliations and a list of published articles.
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19
Citations
827
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0
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Recent Articles
1.
Burton K, Mahen E, Konnick E, Blau S, Dorschner M, Ramirez A, et al.
JCO Precis Oncol
. 2022 Mar;
6:e2100280.
PMID: 35294224
Purpose: Patients with metastatic triple-negative breast cancer (mTNBC) have poor outcomes. The Intensive Trial of Omics in Cancer (ITOMIC) sought to determine the feasibility and potential efficacy of informing treatment...
2.
LaRocca T, Seeger T, Prado M, Perea-Gil I, Neofytou E, Mecham B, et al.
Circ Heart Fail
. 2020 Mar;
13(3):e006298.
PMID: 32160771
Background: MicroRNAs are small, noncoding RNAs that play a key role in gene expression. Accumulating evidence suggests that aberrant microRNA expression contributes to the heart failure (HF) phenotype; however, the...
3.
Blau C, Ramirez A, Blau S, Pritchard C, Dorschner M, Schmechel S, et al.
J Natl Compr Canc Netw
. 2016 Jan;
14(1):8-17.
PMID: 26733551
Accelerating cancer research is expected to require new types of clinical trials. This report describes the Intensive Trial of OMics in Cancer (ITOMIC) and a participant with triple-negative breast cancer...
4.
Homayounfar N, Park S, Afsharinejad Z, Bammler T, MacDonald J, Farin F, et al.
Arch Oral Biol
. 2015 Jul;
60(9):1450-60.
PMID: 26188427
Objective: Previous investigations suggest that the embryonic origins of the calvarial tissues (neural crest or mesoderm) may account for the molecular mechanisms underlying sutural development. The aim of this study...
5.
Osteoblast differentiation profiles define sex specific gene expression patterns in craniosynostosis
Park S, Beyer R, Smyth M, Clarke C, Timms A, Bammler T, et al.
Bone
. 2015 Mar;
76:169-76.
PMID: 25753363
Single suture craniosynostosis (SSC) is the premature fusion of one calvarial suture and occurs in 1-1700-2500 live births. Congenital fusion of either the sagittal, metopic, or coronal sutures represents 95%...
6.
Mangravite L, Engelhardt B, Medina M, Smith J, Brown C, Chasman D, et al.
Nature
. 2013 Sep;
502(7471):377-80.
PMID: 23995691
Statins are prescribed widely to lower plasma low-density lipoprotein (LDL) concentrations and cardiovascular disease risk and have been shown to have beneficial effects in a broad range of patients. However,...
7.
Bilal E, Dutkowski J, Guinney J, Jang I, Logsdon B, Pandey G, et al.
PLoS Comput Biol
. 2013 May;
9(5):e1003047.
PMID: 23671412
Breast cancer is the most common malignancy in women and is responsible for hundreds of thousands of deaths annually. As with most cancers, it is a heterogeneous disease and different...
8.
Margolin A, Bilal E, Huang E, Norman T, Ottestad L, Mecham B, et al.
Sci Transl Med
. 2013 Apr;
5(181):181re1.
PMID: 23596205
Although molecular prognostics in breast cancer are among the most successful examples of translating genomic analysis to clinical applications, optimal approaches to breast cancer clinical risk prediction remain controversial. The...
9.
Mecham B, Nelson P, Storey J
Bioinformatics
. 2010 Apr;
26(10):1308-15.
PMID: 20363728
Motivation: A major challenge in utilizing microarray technologies to measure nucleic acid abundances is 'normalization', the goal of which is to separate biologically meaningful signal from other confounding sources of...
10.
Ware C, Wang L, Mecham B, Shen L, Nelson A, Bar M, et al.
Cell Stem Cell
. 2009 Apr;
4(4):359-69.
PMID: 19341625
Recent evidence indicates that mouse and human embryonic stem cells (ESCs) are fixed at different developmental stages, with the former positioned earlier. We show that a narrow concentration of the...