Brigham H Mecham
Overview
Explore the profile of Brigham H Mecham including associated specialties, affiliations and a list of published articles.
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19
Citations
827
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Recent Articles
11.
Kho A, Bhattacharya S, Mecham B, Hong J, Kohane I, Mariani T
Am J Respir Cell Mol Biol
. 2008 Jul;
40(1):47-57.
PMID: 18664640
A greater understanding of the regulatory processes contributing to lung development could help ameliorate morbidity and mortality in premature infants and identify individuals at risk for congenital and/or chronic lung...
12.
Kassim S, Gharib S, Mecham B, Birkland T, Parks W, McGuire J
Infect Immun
. 2007 Oct;
75(12):5640-50.
PMID: 17923522
Airway epithelium is the initial point of host-pathogen interaction in Pseudomonas aeruginosa infection, an important pathogen in cystic fibrosis and nosocomial pneumonia. We used global gene expression analysis to determine...
13.
Bianchi-Frias D, Pritchard C, Mecham B, Coleman I, Nelson P
Genome Biol
. 2007 Jun;
8(6):R117.
PMID: 17577413
Background: Cancer of the prostate is influenced by both genetic predisposition and environmental factors. The identification of genes capable of modulating cancer development has the potential to unravel disease heterogeneity...
14.
Chu E, Cheng J, Foley J, Mecham B, Owen C, Haley K, et al.
Am J Respir Cell Mol Biol
. 2006 Jun;
35(6):628-38.
PMID: 16794260
Mechanical stimulation of the airway epithelium, as would occur during bronchoconstriction, is a potent stimulus and can activate profibrotic pathways. We used DNA microarray technology to examine gene expression in...
15.
DeMeo D, Mariani T, Lange C, Srisuma S, Litonjua A, Celedon J, et al.
Am J Hum Genet
. 2005 Dec;
78(2):253-64.
PMID: 16358219
Chronic obstructive pulmonary disease (COPD) is a complex human disease likely influenced by multiple genes, cigarette smoking, and gene-by-smoking interactions, but only severe alpha 1-antitrypsin deficiency is a proven genetic...
16.
Carter S, Eklund A, Mecham B, Kohane I, Szallasi Z
BMC Bioinformatics
. 2005 Apr;
6:107.
PMID: 15850491
Background: Comparison of data produced on different microarray platforms often shows surprising discordance. It is not clear whether this discrepancy is caused by noisy data or by improper probe matching...
17.
Mecham B, Wetmore D, Szallasi Z, Sadovsky Y, Kohane I, Mariani T
Physiol Genomics
. 2004 May;
18(3):308-15.
PMID: 15161964
Microarrays have been extensively used to investigate genome-wide expression patterns. Although this technology has been tremendously successful, it has suffered from suboptimal individual measurement precision. Significant improvements in this respect...
18.
Mecham B, Klus G, Strovel J, Augustus M, Byrne D, Bozso P, et al.
Nucleic Acids Res
. 2004 May;
32(9):e74.
PMID: 15161944
Cancer derived microarray data sets are routinely produced by various platforms that are either commercially available or manufactured by academic groups. The fundamental difference in their probe selection strategies holds...
19.
Mariani T, Budhraja V, Mecham B, Gu C, Watson M, Sadovsky Y
FASEB J
. 2002 Dec;
17(2):321-3.
PMID: 12475896
The use of expression microarrays to determine bona fide changes in gene expression between experimental paradigms is confounded by noise due to variability in measurement. To assess the variability associated...