Janusz Dutkowski
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Explore the profile of Janusz Dutkowski including associated specialties, affiliations and a list of published articles.
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22
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1162
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Recent Articles
1.
Duchnowska R, Supernat A, Peksa R, Lukasiewicz M, Stokowy T, Ronen R, et al.
Sci Rep
. 2022 Nov;
12(1):20537.
PMID: 36446793
Brain metastases (BMs) in ovarian cancer (OC) are a rare event. BMs occur most frequently in high-grade serous (HGS) OC. The molecular features of BMs in HGSOC are poorly understood....
2.
Sachdev P, Ronen R, Dutkowski J, Littlefield B
Cancers (Basel)
. 2022 Sep;
14(18).
PMID: 36139690
Eribulin, a natural product-based microtubule targeting agent with cytotoxic and noncytotoxic mechanisms, is FDA approved for certain patients with advanced breast cancer and liposarcoma. To investigate the feasibility of developing...
3.
Burton K, Mahen E, Konnick E, Blau S, Dorschner M, Ramirez A, et al.
JCO Precis Oncol
. 2022 Mar;
6:e2100280.
PMID: 35294224
Purpose: Patients with metastatic triple-negative breast cancer (mTNBC) have poor outcomes. The Intensive Trial of Omics in Cancer (ITOMIC) sought to determine the feasibility and potential efficacy of informing treatment...
4.
Yu M, Kramer M, Dutkowski J, Srivas R, Licon K, Kreisberg J, et al.
Cell Syst
. 2016 Mar;
2(2):77-88.
PMID: 26949740
Accurately translating genotype to phenotype requires accounting for the functional impact of genetic variation at many biological scales. Here we present a strategy for genotype-phenotype reasoning based on existing knowledge...
5.
Blau C, Ramirez A, Blau S, Pritchard C, Dorschner M, Schmechel S, et al.
J Natl Compr Canc Netw
. 2016 Jan;
14(1):8-17.
PMID: 26733551
Accelerating cancer research is expected to require new types of clinical trials. This report describes the Intensive Trial of OMics in Cancer (ITOMIC) and a participant with triple-negative breast cancer...
6.
Tremoulet A, Dutkowski J, Sato Y, Kanegaye J, Ling X, Burns J
Pediatr Res
. 2015 Aug;
78(5):547-53.
PMID: 26237629
Background: As Kawasaki disease (KD) shares many clinical features with other more common febrile illnesses and misdiagnosis, leading to a delay in treatment, increases the risk of coronary artery damage,...
7.
Kramer M, Dutkowski J, Yu M, Bafna V, Ideker T
Bioinformatics
. 2014 Jun;
30(12):i34-42.
PMID: 24932003
Motivation: While the manually curated Gene Ontology (GO) is widely used, inferring a GO directly from -omics data is a compelling new problem. Recognizing that ontologies are a directed acyclic...
8.
Joshi S, Singh A, Zulcic M, Bao L, Messer K, Ideker T, et al.
PLoS One
. 2014 Apr;
9(4):e95893.
PMID: 24770346
Although it is well-established that the macrophage M1 to M2 transition plays a role in tumor progression, the molecular basis for this process remains incompletely understood. Herein, we demonstrate that...
9.
Dutkowski J, Ono K, Kramer M, Yu M, Pratt D, Demchak B, et al.
Nucleic Acids Res
. 2013 Nov;
42(Database issue):D1269-74.
PMID: 24271398
The Network-extracted Ontology (NeXO) is a gene ontology inferred directly from large-scale molecular networks. While most ontologies are constructed through manual expert curation, NeXO uses a principled computational approach which...
10.
Dutkowski J, Tiuryn J
J Comput Biol
. 2013 Aug;
20(9):631-42.
PMID: 23931333
Comparative approaches in genomics have long relied on rigorous mathematical models of sequence evolution. Such models provide the basis for formulating and solving well-defined computational problems, in turn yielding key...