Brian Raught
Overview
Explore the profile of Brian Raught including associated specialties, affiliations and a list of published articles.
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Articles
169
Citations
9335
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Recent Articles
11.
Sheth A, Althoff M, Tolison H, Engel K, Amaya M, Krug A, et al.
Cancer Discov
. 2024 May;
14(10):1922-1939.
PMID: 38787341
Acute myeloid leukemia stem cells (LSCs) are uniquely reliant on oxidative phosphorylation (OXPHOS) for survival. Moreover, maintenance of OXPHOS is dependent on BCL-2, creating a therapeutic opportunity to target LSCs...
12.
Zhu H, Sydor A, Boddy K, Coyaud E, Laurent E, Au A, et al.
Nat Commun
. 2024 Apr;
15(1):3120.
PMID: 38600106
Salmonella utilizes a type 3 secretion system to translocate virulence proteins (effectors) into host cells during infection. The effectors modulate host cell machinery to drive uptake of the bacteria into...
13.
Yerlici V, Astori A, Kejiou N, Jordan C, Khosraviani N, Chan J, et al.
Cell Rep
. 2024 Mar;
43(3):113891.
PMID: 38427561
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hinders host gene expression, curbing defenses and licensing viral protein synthesis and virulence. During SARS-CoV-2 infection, the virulence factor non-structural protein 1 (Nsp1)...
14.
Mao Y, Seraphim T, Wan Y, Wu R, Coyaud E, Munim M, et al.
Cell Rep
. 2024 Feb;
43(2):113713.
PMID: 38306274
R2TP is a chaperone complex consisting of the AAA+ ATPases RUVBL1 and RUVBL2, as well as RPAP3 and PIH1D1 proteins. R2TP is responsible for the assembly of macromolecular complexes mainly...
15.
Giacomini G, Piquet S, Chevallier O, Dabin J, Bai S, Kim B, et al.
Nucleic Acids Res
. 2024 Jan;
52(5):2372-2388.
PMID: 38214234
Pediatric high-grade gliomas (pHGG) are devastating and incurable brain tumors with recurrent mutations in histone H3.3. These mutations promote oncogenesis by dysregulating gene expression through alterations of histone modifications. We...
16.
Goyon V, Besse-Patin A, Zunino R, Ignatenko O, Nguyen M, Coyaud E, et al.
EMBO Rep
. 2023 Nov;
24(12):e57972.
PMID: 37962001
Mitochondrial and peroxisomal anchored protein ligase (MAPL) is a dual ubiquitin and small ubiquitin-like modifier (SUMO) ligase with roles in mitochondrial quality control, cell death and inflammation in cultured cells....
17.
Nie D, Tabor J, Li J, Kutera M, St-Germain J, Hanley R, et al.
bioRxiv
. 2023 Nov;
PMID: 37961297
Targeted protein degradation (TPD) is an emerging therapeutic strategy that would benefit from new chemical entities with which to recruit a wider variety of ubiquitin E3 ligases to target proteins...
18.
Sheth A, Engel K, Tolison H, Althoff M, Amaya M, Krug A, et al.
bioRxiv
. 2023 Oct;
PMID: 37873284
We previously reported that acute myeloid leukemia stem cells (LSCs) are uniquely reliant on oxidative phosphorylation (OXPHOS) for survival. Moreover, maintenance of OXPHOS is dependent on BCL2, creating a therapeutic...
19.
Iazzi M, St-Germain J, Acharya S, Raught B, Gupta G
Methods Mol Biol
. 2023 Oct;
2725:181-198.
PMID: 37856025
The primary cilium is a highly conserved microtubule-based organelle present in most vertebrate cell types. Mutations in ciliary protein genes can lead to dysfunctional or absent cilia and are the...
20.
Kugler E, Madiwale S, Yong D, Thoms J, Birger Y, Sykes D, et al.
Nat Commun
. 2023 Sep;
14(1):5871.
PMID: 37735473
The ERG (ETS-related gene) transcription factor is linked to various types of cancer, including leukemia. However, the specific ERG domains and co-factors contributing to leukemogenesis are poorly understood. Drug targeting...