John H Brumell
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Explore the profile of John H Brumell including associated specialties, affiliations and a list of published articles.
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135
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13984
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Recent Articles
1.
Zhu H, Sydor A, Yan B, Li R, Boniecki M, Lyons C, et al.
Nat Commun
. 2025 Mar;
16(1):2329.
PMID: 40057496
Salmonella utilizes type 3 secreted effector proteins to induce plasma membrane (PM) perturbations during invasion of host cells. The effectors drive mobilization of host membranes to generate cell surface ruffles,...
2.
Jang E, Ho T, Brumell J, Lefebvre F, Wang C, Lee W
Arterioscler Thromb Vasc Biol
. 2024 Jul;
44(9):2053-2068.
PMID: 38989581
Background: In early atherosclerosis, circulating LDLs (low-density lipoproteins) traverse individual endothelial cells by an active process termed transcytosis. The CANTOS trial (Canakinumab Antiinflammatory Thrombosis Outcome Study) treated advanced atherosclerosis using...
3.
Herrera A, Packer M, Rosas-Lemus M, Minasov G, Chen J, Brumell J, et al.
Proc Natl Acad Sci U S A
. 2024 Jun;
121(25):e2316143121.
PMID: 38861595
causes life-threatening wound and gastrointestinal infections, mediated primarily by the production of a Multifunctional-Autoprocessing Repeats-In-Toxin (MARTX) toxin. The most commonly present MARTX effector domain, the Makes Caterpillars Floppy-like (MCF) toxin,...
4.
Zhu H, Sydor A, Boddy K, Coyaud E, Laurent E, Au A, et al.
Nat Commun
. 2024 Apr;
15(1):3120.
PMID: 38600106
Salmonella utilizes a type 3 secretion system to translocate virulence proteins (effectors) into host cells during infection. The effectors modulate host cell machinery to drive uptake of the bacteria into...
5.
Chi L, Lee D, Leung S, Hu G, Wen B, Delgado-Olguin P, et al.
Cell Mol Life Sci
. 2023 Jun;
80(7):183.
PMID: 37338571
Peroxisomes are essential for mitochondrial health, as the absence of peroxisomes leads to altered mitochondria. However, it is unclear whether the changes in mitochondria are a function of preserving cellular...
6.
Bhosle V, Tan J, Li T, Hua R, Kwon H, Li Z, et al.
Life Sci Alliance
. 2023 Jun;
6(8).
PMID: 37311584
SLIT/ROBO signaling impacts many aspects of tissue development and homeostasis, in part, through the regulation of cell growth and proliferation. Recent studies have also linked SLIT/ROBO signaling to the regulation...
7.
Frendo-Cumbo S, Li T, Ammendolia D, Coyaud E, Laurent E, Liu Y, et al.
iScience
. 2022 Dec;
25(12):105668.
PMID: 36505937
[This corrects the article DOI: 10.1016/j.isci.2022.105188.].
8.
Frendo-Cumbo S, Li T, Ammendolia D, Coyaud E, Laurent E, Liu Y, et al.
iScience
. 2022 Oct;
25(10):105188.
PMID: 36248734
Cell proliferation is dependent on growth factors insulin and IGF1. We sought to identify interactors of IRS1, the most proximal mediator of insulin/IGF1 signaling, that regulate cell proliferation. Using proximity-dependent...
9.
Zou A, Nadeau K, Xiong X, Wang P, Copeland J, Lee J, et al.
Microbiome
. 2022 Aug;
10(1):127.
PMID: 35965349
Background: The emergence of antimicrobial resistance is a major threat to global health and has placed pressure on the livestock industry to eliminate the use of antibiotic growth promotants (AGPs)...
10.
Yazdani S, Bilan P, Jaldin-Fincati J, Pang J, Ceban F, Saran E, et al.
Mol Biol Cell
. 2022 Aug;
33(12):ar106.
PMID: 35921166
Endothelia determine blood-to-tissue solute delivery, yet glucose transit is poorly understood. To illuminate mechanisms, we tracked [H]-2-deoxyglucose (2-DG) in human adipose-tissue microvascular endothelial cells. 2-DG uptake was largely facilitated by...