Brian Raught
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Explore the profile of Brian Raught including associated specialties, affiliations and a list of published articles.
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Articles
169
Citations
9335
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Recent Articles
21.
Krishnan R, Lapierre M, Gautreau B, Nixon K, El Ghamrasni S, Patel P, et al.
Nucleic Acids Res
. 2023 Sep;
51(19):10484-10505.
PMID: 37697435
Breast cancer linked with BRCA1/2 mutations commonly recur and resist current therapies, including PARP inhibitors. Given the lack of effective targeted therapies for BRCA1-mutant cancers, we sought to identify novel...
22.
OBrien C, Ling T, Berman J, Culp-Hill R, Reisz J, Rondeau V, et al.
Haematologica
. 2023 Apr;
108(9):2343-2357.
PMID: 37021547
Outcomes for patients with acute myeloid leukemia (AML) remain poor due to the inability of current therapeutic regimens to fully eradicate disease-initiating leukemia stem cells (LSC). Previous studies have demonstrated...
23.
Lewis M, Terre B, Knobel P, Cheng T, Lu H, Stephan-Otto Attolini C, et al.
Cell Death Dis
. 2023 Mar;
14(3):201.
PMID: 36932059
Multiciliated cells (MCCs) project dozens to hundreds of motile cilia from their apical surface to promote the movement of fluids or gametes in the mammalian brain, airway or reproductive organs....
24.
Paul I, Bolzan D, Youssef A, Gagnon K, Hook H, Karemore G, et al.
Nat Commun
. 2023 Feb;
14(1):688.
PMID: 36755019
A proper understanding of disease etiology will require longitudinal systems-scale reconstruction of the multitiered architecture of eukaryotic signaling. Here we combine state-of-the-art data acquisition platforms and bioinformatics tools to devise...
25.
Chan K, Farias A, Lee H, Guvenc F, Mero P, Brown K, et al.
Heliyon
. 2023 Jan;
9(1):e12744.
PMID: 36597481
SARS-CoV-2 depends on host cell components for infection and replication. Identification of virus-host dependencies offers an effective way to elucidate mechanisms involved in viral infection and replication. If druggable, host...
26.
Frendo-Cumbo S, Li T, Ammendolia D, Coyaud E, Laurent E, Liu Y, et al.
iScience
. 2022 Dec;
25(12):105668.
PMID: 36505937
[This corrects the article DOI: 10.1016/j.isci.2022.105188.].
27.
Shankar S, Hsu Z, Ezquerra A, Li C, Huang T, Coyaud E, et al.
Cell Rep
. 2022 Nov;
41(7):111642.
PMID: 36384111
The primary cilium, a microtubule-based sensory organelle, undergoes cycles of assembly and disassembly that govern the cell cycle progression critical to cell proliferation and differentiation. Although cilia assembly has been...
28.
Frendo-Cumbo S, Li T, Ammendolia D, Coyaud E, Laurent E, Liu Y, et al.
iScience
. 2022 Oct;
25(10):105188.
PMID: 36248734
Cell proliferation is dependent on growth factors insulin and IGF1. We sought to identify interactors of IRS1, the most proximal mediator of insulin/IGF1 signaling, that regulate cell proliferation. Using proximity-dependent...
29.
Siddaway R, Milos S, Coyaud E, Yun H, Morcos S, Pajovic S, et al.
Mol Cell Proteomics
. 2022 Sep;
21(10):100411.
PMID: 36089195
Chromatin structure, transcription, DNA replication, and repair are regulated via locus-specific incorporation of histone variants and posttranslational modifications that guide effector chromatin-binding proteins. Here we report unbiased, quantitative interactomes for...
30.
Siddaway R, Canty L, Pajovic S, Milos S, Coyaud E, Sbergio S, et al.
Acta Neuropathol
. 2022 Sep;
144(5):1027-1048.
PMID: 36070144
Histone H3 mutations at amino acids 27 (H3K27M) and 34 (H3G34R) are recurrent drivers of pediatric-type high-grade glioma (pHGG). H3K27M mutations lead to global disruption of H3K27me3 through dominant negative...