Jonathan St-Germain
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Explore the profile of Jonathan St-Germain including associated specialties, affiliations and a list of published articles.
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30
Citations
542
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Recent Articles
1.
Feng Y, Goncalves M, Jitkova Y, Keszei A, Yan Y, Sarathy C, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(5):e2422447122.
PMID: 39879245
ClpXP is a two-component mitochondrial matrix protease. The caseinolytic mitochondrial matrix peptidase chaperone subunit X (ClpX) recognizes and translocates protein substrates into the degradation chamber of the caseinolytic protease P...
2.
Nucleolar Pol II interactome reveals TBPL1, PAF1, and Pol I at intergenic rDNA drive rRNA biogenesis
Khosraviani N, Yerlici V, St-Germain J, Hou Y, Cao S, Ghali C, et al.
Nat Commun
. 2024 Nov;
15(1):9603.
PMID: 39505901
Ribosomal DNA (rDNA) repeats harbor ribosomal RNA (rRNA) genes and intergenic spacers (IGS). RNA polymerase (Pol) I transcribes rRNA genes yielding rRNA components of ribosomes. IGS-associated Pol II prevents Pol...
3.
Rondeau V, Berman J, Ling T, OBrien C, Culp-Hill R, Reisz J, et al.
Sci Transl Med
. 2024 Sep;
16(766):eadn1285.
PMID: 39321266
Acute myeloid leukemia (AML) is a devastating disease initiated and maintained by a rare subset of cells called leukemia stem cells (LSCs). LSCs are responsible for driving disease relapse, making...
4.
Walton J, Ng A, Arevalo K, Apostoli A, Meens J, Karamboulas C, et al.
Nat Commun
. 2024 Sep;
15(1):8232.
PMID: 39300069
In addition to the ubiquitous loss of the VHL gene in clear cell renal cell carcinoma (ccRCC), co-deletions of chromatin-regulating genes are common drivers of tumorigenesis, suggesting potential vulnerability to...
5.
Nie D, Tabor J, Li J, Kutera M, St-Germain J, Hanley R, et al.
Nat Chem Biol
. 2024 Jul;
20(12):1597-1607.
PMID: 38965384
Targeted protein degradation (TPD) is an emerging therapeutic strategy that would benefit from new chemical entities with which to recruit a wider variety of ubiquitin E3 ligases to target proteins...
6.
Sheth A, Althoff M, Tolison H, Engel K, Amaya M, Krug A, et al.
Cancer Discov
. 2024 May;
14(10):1922-1939.
PMID: 38787341
Acute myeloid leukemia stem cells (LSCs) are uniquely reliant on oxidative phosphorylation (OXPHOS) for survival. Moreover, maintenance of OXPHOS is dependent on BCL-2, creating a therapeutic opportunity to target LSCs...
7.
Nie D, Tabor J, Li J, Kutera M, St-Germain J, Hanley R, et al.
bioRxiv
. 2023 Nov;
PMID: 37961297
Targeted protein degradation (TPD) is an emerging therapeutic strategy that would benefit from new chemical entities with which to recruit a wider variety of ubiquitin E3 ligases to target proteins...
8.
Sheth A, Engel K, Tolison H, Althoff M, Amaya M, Krug A, et al.
bioRxiv
. 2023 Oct;
PMID: 37873284
We previously reported that acute myeloid leukemia stem cells (LSCs) are uniquely reliant on oxidative phosphorylation (OXPHOS) for survival. Moreover, maintenance of OXPHOS is dependent on BCL2, creating a therapeutic...
9.
Iazzi M, St-Germain J, Acharya S, Raught B, Gupta G
Methods Mol Biol
. 2023 Oct;
2725:181-198.
PMID: 37856025
The primary cilium is a highly conserved microtubule-based organelle present in most vertebrate cell types. Mutations in ciliary protein genes can lead to dysfunctional or absent cilia and are the...
10.
Krishnan R, Lapierre M, Gautreau B, Nixon K, El Ghamrasni S, Patel P, et al.
Nucleic Acids Res
. 2023 Sep;
51(19):10484-10505.
PMID: 37697435
Breast cancer linked with BRCA1/2 mutations commonly recur and resist current therapies, including PARP inhibitors. Given the lack of effective targeted therapies for BRCA1-mutant cancers, we sought to identify novel...