Brent R Martin
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Explore the profile of Brent R Martin including associated specialties, affiliations and a list of published articles.
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44
Citations
1998
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Recent Articles
21.
Martin B, Lambert N
J Biol Chem
. 2016 Aug;
291(39):20295-20302.
PMID: 27528603
Heterotrimeric G proteins are localized to the plasma membrane where they transduce extracellular signals to intracellular effectors. G proteins also act at intracellular locations, and can translocate between cellular compartments....
22.
Hernandez J, Davda D, Majmudar J, Won S, Prakash A, Choi A, et al.
Mol Biosyst
. 2016 Apr;
12(6):1799-808.
PMID: 27030425
Epithelial cells form spatially-organized adhesion complexes that establish polarity gradients, regulate cell proliferation, and direct wound healing. As cells accumulate oncogenic mutations, these key tumor suppression mechanisms are disrupted, eliminating...
23.
Majmudar J, Konopko A, Labby K, Tom C, Crellin J, Prakash A, et al.
J Am Chem Soc
. 2016 Jan;
138(6):1852-9.
PMID: 26780921
Cysteine S-nitrosation and S-sulfination are naturally occurring post-translational modifications (PTMs) on proteins induced by physiological signals and redox stress. Here we demonstrate that sulfinic acids and nitrosothiols react to form...
24.
Foe I, Child M, Majmudar J, Krishnamurthy S, van der Linden W, Ward G, et al.
Cell Host Microbe
. 2015 Oct;
18(4):501-11.
PMID: 26468752
Post-translational modifications (PTMs) such as palmitoylation are critical for the lytic cycle of the protozoan parasite Toxoplasma gondii. While palmitoylation is involved in invasion, motility, and cell morphology, the proteins...
25.
Xu H, Majmudar J, Davda D, Ghanakota P, Kim K, Carlson H, et al.
Mol Pharm
. 2015 Aug;
12(9):3399-407.
PMID: 26262434
Understanding the mechanistic basis of prodrug delivery and activation is critical for establishing species-specific prodrug sensitivities necessary for evaluating preclinical animal models and potential drug-drug interactions. Despite significant adoption of...
26.
Davda D, Martin B
Medchemcomm
. 2015 Jan;
5(3):268-276.
PMID: 25558349
Protein palmitoylation describes the hydrophobic post-translational modification of cysteine residues in certain proteins, and is required for the spatial organization and composition of cellular membrane environments. Certain palmitoylated proteins are...
27.
Martin B
Curr Protoc Protein Sci
. 2014 Feb;
73:14.15.1-14.15.9.
PMID: 24510591
Methods to study protein S-palmitoylation dynamics have previously relied on metabolic labeling with [(14)C]palmitate, which requires additional safety precautions and long exposures. Nonradioactive alkynyl palmitate analogs have been developed for...
28.
Jia L, Chisari M, Maktabi M, Sobieski C, Zhou H, Konopko A, et al.
J Biol Chem
. 2014 Jan;
289(9):6249-57.
PMID: 24385443
Reversible attachment and removal of palmitate or other long-chain fatty acids on proteins has been hypothesized, like phosphorylation, to control diverse biological processes. Indeed, palmitate turnover regulates Ras trafficking and...
29.
30.
Davda D, El Azzouny M, Tom C, Hernandez J, Majmudar J, Kennedy R, et al.
ACS Chem Biol
. 2013 Jul;
8(9):1912-7.
PMID: 23844586
2-Bromohexadecanoic acid, or 2-bromopalmitate, was introduced nearly 50 years ago as a nonselective inhibitor of lipid metabolism. More recently, 2-bromopalmitate re-emerged as a general inhibitor of protein S-palmitoylation. Here, we...