Brent R Martin
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Explore the profile of Brent R Martin including associated specialties, affiliations and a list of published articles.
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44
Citations
1998
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Recent Articles
11.
Lopez J, Haynes S, Majmudar J, Martin B, Fierke C
J Am Chem Soc
. 2017 Oct;
139(45):16222-16227.
PMID: 29035536
The histone deacetylase family comprises 18 enzymes that catalyze deacetylation of acetylated lysine residues; however, the specificity and substrate profile of each isozyme remains largely unknown. Due to transient enzyme-substrate...
12.
Kuo Y, Konopko A, Borotto N, Majmudar J, Haynes S, Martin B
Chembiochem
. 2017 Aug;
18(20):2028-2032.
PMID: 28809078
Cysteine residues are susceptible to oxidation to form S-sulfinyl (R-SO H) and S-sulfonyl (R-SO H) post-translational modifications. Here we present a simple bioconjugation strategy to label S-sulfinated proteins by using...
13.
Borotto N, McClory P, Martin B, Hakansson K
Anal Chem
. 2017 Jul;
89(16):8304-8310.
PMID: 28708386
Protein S-sulfinylation (R-SO) and S-sulfonylation (R-SO) are irreversible oxidative post-translational modifications of cysteine residues. Greater than 5% of cysteines are reported to occupy these higher oxidation states, which effectively inactivate...
14.
Tom C, Crellin J, Motiwala H, Stone M, Davda D, Walker W, et al.
Chem Commun (Camb)
. 2017 Jun;
53(53):7385-7388.
PMID: 28613292
Here we report a ratiometric fluorescent probe for chemoselective conjugation to sulfenic acids in living cells. Our approach couples an α-fluoro-substituted dimedone to an aminonaphthalene fluorophore (F-DiNap), which upon sulfenic...
15.
Haynes S, Polasky D, Dixit S, Majmudar J, Neeson K, Ruotolo B, et al.
Anal Chem
. 2017 May;
89(11):5669-5672.
PMID: 28471653
High mass accuracy, data-dependent acquisition is the current standard method in mass spectrometry-based peptide annotation and quantification. In high complexity samples, limited instrument scan speeds often result in under-sampling. In...
16.
Won S, Eschweiler J, Majmudar J, Chong F, Hwang S, Ruotolo B, et al.
ACS Med Chem Lett
. 2017 Feb;
8(2):215-220.
PMID: 28197315
Activity-based protein profiling (ABPP) has revolutionized the discovery and optimization of active-site ligands across distinct enzyme families, providing a robust platform for in-class selectivity profiling. Nonetheless, this approach is less...
17.
ElAzzouny M, Tom C, Evans C, Olson L, Tanga M, Gallagher K, et al.
J Biol Chem
. 2017 Feb;
292(12):4766-4769.
PMID: 28188288
Itaconic acid is an important metabolite produced by macrophages after stimulation with LPS. The role of itaconate in the inflammatory cascade is unclear. Here we used [C]itaconate and dimethyl [C]itaconate...
18.
Hernandez J, Davda D, Cheung See Kit M, Majmudar J, Won S, Gang M, et al.
Cell Chem Biol
. 2017 Jan;
24(1):87-97.
PMID: 28065656
The multidomain scaffolding protein Scribble (Scrib) organizes key signaling complexes to specify basolateral cell polarity and suppress aberrant growth. In many human cancers, genetically normal Scrib mislocalizes from cell-cell junctions...
19.
20.
Won S, Davda D, Labby K, Hwang S, Pricer R, Majmudar J, et al.
ACS Chem Biol
. 2016 Nov;
11(12):3374-3382.
PMID: 27748579
Post-translational S-palmitoylation directs the trafficking and membrane localization of hundreds of cellular proteins, often involving a coordinated palmitoylation cycle that requires both protein acyl transferases (PATs) and acyl protein thioesterases...