Hashim F Motiwala
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Explore the profile of Hashim F Motiwala including associated specialties, affiliations and a list of published articles.
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15
Citations
234
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Recent Articles
1.
Motiwala H, Armaly A, Cacioppo J, Coombs T, Koehn K, Norwood 4th V, et al.
Chem Rev
. 2022 Jul;
122(15):12544-12747.
PMID: 35848353
1,1,1,3,3,3-Hexafluoroisopropanol (HFIP) is a polar, strongly hydrogen bond-donating solvent that has found numerous uses in organic synthesis due to its ability to stabilize ionic species, transfer protons, and engage in...
2.
Motiwala H, Kuo Y, Stinger B, Palfey B, Martin B
J Am Chem Soc
. 2019 Dec;
142(4):1801-1810.
PMID: 31881155
Heteroaromatic sulfones react with cysteine via nucleophilic aromatic substitution, providing a mechanistically selective and irreversible scaffold for cysteine conjugation. Here we evaluate a library of heteroaromatic sulfides with different oxidation...
3.
Charaschanya M, Li K, Motiwala H, Aube J
Org Lett
. 2018 Oct;
20(20):6354-6358.
PMID: 30277406
The rerouting of the nitrilium ion formed in the Schmidt reaction of ketones and TMSN to encompass C-C bond formation with an electron-rich aromatic group is reported. Thus, when the...
4.
Tom C, Crellin J, Motiwala H, Stone M, Davda D, Walker W, et al.
Chem Commun (Camb)
. 2017 Jun;
53(53):7385-7388.
PMID: 28613292
Here we report a ratiometric fluorescent probe for chemoselective conjugation to sulfenic acids in living cells. Our approach couples an α-fluoro-substituted dimedone to an aminonaphthalene fluorophore (F-DiNap), which upon sulfenic...
5.
6.
White P, Subramanian C, Motiwala H, Cohen M
Adv Exp Med Biol
. 2016 Sep;
928:329-373.
PMID: 27671823
Withanolides, and in particular extracts from Withania somnifera, have been used for over 3,000 years in traditional Ayurvedic and Unani Indian medical systems as well as within several other Asian...
7.
Byrd K, Subramanian C, Sanchez J, Motiwala H, Liu W, Cohen M, et al.
Chemistry
. 2016 Apr;
22(20):6921-31.
PMID: 27037933
Development of heat shock protein 90 (Hsp90) C-terminal inhibitors has emerged as an exciting strategy for the treatment of cancer. Previous efforts have focused on modifications to the natural products...
8.
Motiwala H, Charaschanya M, Day V, Aube J
J Org Chem
. 2016 Jan;
81(4):1593-609.
PMID: 26800244
The effect of carrying out two variations of the Schmidt reaction with ketone electrophiles in hexafluoroisopropanol (HFIP) solvent has been studied. When TMSN3 is reacted with ketones in the presence...
9.
Motiwala H, Yin Q, Aube J
Molecules
. 2016 Jan;
21(1):E45.
PMID: 26729081
The Schmidt reaction of aromatic aldehydes using a substoichiometric amount (40 mol %) of triflic acid is described. Low catalyst loading was enabled by a strong hydrogen-bond-donating solvent hexafluoro-2-propanol (HFIP)....
10.
Motiwala H, Vekariya R, Aube J
Org Lett
. 2015 Oct;
17(21):5484-7.
PMID: 26496158
Simple dissolution of an arylalkyl acid chloride in 1,1,1,3,3,3-hexafluoro-2-propanol promotes an intramolecular Friedel-Crafts acylation without additional catalysts or reagents. This reaction is operationally trivial in both execution and product isolation...