Brent R Martin
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Explore the profile of Brent R Martin including associated specialties, affiliations and a list of published articles.
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44
Citations
1998
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Recent Articles
1.
Takahashi M, Chong H, Zhang S, Yang T, Lazarov M, Harry S, et al.
Cell
. 2024 Apr;
187(10):2536-2556.e30.
PMID: 38653237
Cysteine-focused chemical proteomic platforms have accelerated the clinical development of covalent inhibitors for a wide range of targets in cancer. However, how different oncogenic contexts influence cysteine targeting remains unknown....
2.
Zhao D, Yin Z, Soellner M, Martin B
Cell Chem Biol
. 2021 Mar;
28(8):1235-1241.e5.
PMID: 33730553
The multi-domain scaffolding protein Scribble (Scrib) regulates cell polarity and growth signaling at cell-cell junctions. In epithelial cancers, Scrib mislocalization and overexpression paradoxically transform Scrib from a basolateral tumor suppressor...
3.
Lisabeth E, Kahl D, Gopallawa I, Haynes S, Misek S, Campbell P, et al.
ACS Pharmacol Transl Sci
. 2020 Feb;
2(2):92-100.
PMID: 32039344
A series of compounds (including CCG-1423 and CCG-203971) discovered through an MRTF/SRF-dependent luciferase screen has shown remarkable efficacy in a variety of and models, including significant reduction of melanoma metastasis...
4.
Motiwala H, Kuo Y, Stinger B, Palfey B, Martin B
J Am Chem Soc
. 2019 Dec;
142(4):1801-1810.
PMID: 31881155
Heteroaromatic sulfones react with cysteine via nucleophilic aromatic substitution, providing a mechanistically selective and irreversible scaffold for cysteine conjugation. Here we evaluate a library of heteroaromatic sulfides with different oxidation...
5.
Ko P, Woodrow C, Dubreuil M, Martin B, Skouta R, Bassik M, et al.
Cell Chem Biol
. 2019 Oct;
26(12):1716-1724.e9.
PMID: 31631010
Lethal small molecules are useful probes to discover and characterize novel cell death pathways and biochemical mechanisms. Here we report that the synthetic oxime-containing small molecule caspase-independent lethal 56 (CIL56)...
6.
Cheung See Kit M, Martin B
Methods Mol Biol
. 2019 Jun;
2009:71-79.
PMID: 31152396
As the 10-year anniversary of their first introduction approaches, alkynyl fatty acids have revolutionized the analysis of S-palmitoylation dynamics, acting as functional mimics incorporated into native modification sites in cultured...
7.
Borotto N, Ileka K, Tom C, Martin B, Hakansson K
Anal Chem
. 2018 Aug;
90(16):9682-9686.
PMID: 30063332
Tandem mass spectrometry (MS/MS) is the primary method for discovering, identifying, and localizing post-translational modifications (PTMs) in proteins. However, conventional positive ion mode collision induced dissociation (CID)-based MS/MS often fails...
8.
Haynes S, Majmudar J, Martin B
Anal Chem
. 2018 Jul;
90(15):8722-8726.
PMID: 29989796
Quantitative mass spectrometry-based protein profiling is widely used to measure protein levels across different treatments or disease states, yet current mass spectrometry acquisition methods present distinct limitations. While data-independent acquisition...
9.
Won S, Martin B
ACS Chem Biol
. 2018 May;
13(6):1560-1568.
PMID: 29733200
S-palmitoylation is required for membrane anchoring, proper trafficking, and the normal function of hundreds of integral and peripheral membrane proteins. Previous bioorthogonal pulse-chase proteomics analyses identified Ras family GTPases, polarity...
10.
Won S, Cheung See Kit M, Martin B
Crit Rev Biochem Mol Biol
. 2017 Dec;
53(1):83-98.
PMID: 29239216
Protein depalmitoylation describes the removal of thioester-linked long chain fatty acids from cysteine residues in proteins. For many S-palmitoylated proteins, this process is promoted by acyl protein thioesterase enzymes, which...