Bharath Srinivasan
Overview
Explore the profile of Bharath Srinivasan including associated specialties, affiliations and a list of published articles.
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Articles
47
Citations
299
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Recent Articles
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James J, Pahal S, Jayaraman A, Nayak A D, Koteshwar Narasimhachar S, Sundarrajan S, et al.
Macromol Biosci
. 2024 Dec;
25(3):e2400485.
PMID: 39704612
Biologics targeting matrix-degrading proteases, cartilage repair, and inflammation are emerging as promising approaches for osteoarthritis (OA) treatment. Recent research highlights biologic-human placental tissue (HPT) as a potential OA therapy due...
3.
Srinivasan B, Lloyd M
J Med Chem
. 2024 Oct;
67(20):17931-17934.
PMID: 39356832
No abstract available.
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Smith J, Barlaam B, Beattie D, Bradshaw L, Chan H, Chiarparin E, et al.
J Med Chem
. 2024 Jul;
67(16):13604-13638.
PMID: 39080842
PRMT5, a type 2 arginine methyltransferase, has a critical role in regulating cell growth and survival in cancer. With the aim of developing MTA-cooperative PRMT5 inhibitors suitable for MTAP-deficient cancers,...
6.
Hegde A, Kunder M, Narayanaswamy M, Murugesan S, Furtado S, Basappa Veerabhadraiah B, et al.
Environ Sci Pollut Res Int
. 2024 May;
31(26):38061-38082.
PMID: 38806984
Sunscreens are essential in protecting the skin from harmful effects of ultraviolet radiation (UVR). These formulations, designed to absorb, block, or scatter UVR, offer vital protection against skin aging, sunburns,...
7.
Atkinson S, Bagal S, Argyrou A, Askin S, Cheung T, Chiarparin E, et al.
J Med Chem
. 2024 Mar;
67(6):4541-4559.
PMID: 38466661
The optimization of an allosteric fragment, discovered by differential scanning fluorimetry, to an in vivo MAT2a tool inhibitor is discussed. The structure-based drug discovery approach, aided by relative binding free...
8.
Srinivasan B
Methods Enzymol
. 2023 Oct;
690:85-108.
PMID: 37858541
Most drug target interactions for clinically approved small-molecules are non-equilibrium slow-onset, tight-binding or irreversible in nature, with pronounced element of time-dependence of inhibition. Analysis of such modality of inhibition requires...
9.
Srinivasan B
FEBS J
. 2023 Apr;
290(23):5441-5455.
PMID: 37014311
The ability to view structures of proteins at atomic resolution, facilitated by the rise of macromolecular crystallography, has had a tremendous impact in many areas of sciences, including molecular pharmacology,...
10.
Ravichandran K, Dinesh K, Nagaraja S, Srinivasan B, Shetty N, Ramesh P
J Conserv Dent
. 2022 Oct;
25(4):356-362.
PMID: 36187864
Background: Despite constant advances in science, obscurity remains in the efficient removal of pulp stones to aid in successful root canal treatment. In this context, chemical means of dissolving pulp...