Bharath Srinivasan
Overview
Explore the profile of Bharath Srinivasan including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
47
Citations
299
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Srinivasan B, Florez Weidinger J, Zhai X, Lemercier G, Ikeda T, Brewer M, et al.
SLAS Discov
. 2022 Sep;
27(8):460-470.
PMID: 36156314
Recent efforts for increasing the success in drug discovery focus on an early, massive, and routine mechanistic and/or kinetic characterization of drug-target engagement as part of a design-make-test-analyze strategy. From...
12.
Srinivasan B, Kus K, Athanasiadis A
Biochem J
. 2022 Aug;
479(16):1727-1741.
PMID: 35969150
DNA/RNA molecules adopting the left-handed conformation (Z-form) have been attributed with immunogenic properties. However, their biological role and importance have been a topic of debate for many years. The discovery...
13.
Kantae V, Polanski R, Lewis H, Haider A, Barratt D, Srinivasan B
ACS Chem Biol
. 2022 Jul;
17(8):2366-2376.
PMID: 35881961
Covalent inhibition is a valuable modality in drug discovery because of its potential ability in decoupling pharmacokinetics from pharmacodynamics by prolonging the residence time of the drug on the target...
14.
Srinivasan B
FEBS J
. 2022 Feb;
290(9):2292-2305.
PMID: 35175693
Drugs interact with their target of interest to bring about the desired phenotypic outcome that results in disease alleviation. Traditionally, most lead optimization exercises were driven by affinity measures (like...
15.
Srinivasan B
FEBS J
. 2021 Jul;
289(20):6086-6098.
PMID: 34270860
The modern definition of enzymology is synonymous with the Michaelis-Menten equation instituted by Leonor Michaelis and Maud Menten. Most textbooks, or chapters within, discussing enzymology start with the derivation of...
16.
Gabriel L, Srinivasan B, Kus K, Mata J, Amorim M, Jansen L, et al.
J Cell Sci
. 2021 May;
134(10).
PMID: 34037233
Zα domains recognize the left-handed helical Z conformation of double-stranded nucleic acids. They are found in proteins involved in the nucleic acid sensory pathway of the vertebrate innate immune system...
17.
Khurana P, McWilliams L, Wingfield J, Barratt D, Srinivasan B
SLAS Discov
. 2021 Mar;
26(5):684-697.
PMID: 33783249
Target engagement by small molecules is necessary for producing a physiological outcome. In the past, a lot of emphasis was placed on understanding the thermodynamics of such interactions to guide...
18.
Srinivasan B
ChemMedChem
. 2020 Nov;
16(6):899-918.
PMID: 33231926
Biological systems are highly regulated. They are also highly resistant to sudden perturbations enabling them to maintain the dynamic equilibrium essential to sustain life. This robustness is conferred by regulatory...
19.
Kalra S, Aydin H, Sahay M, Ghosh S, Ruder S, Tiwaskar M, et al.
Eur Endocrinol
. 2020 Oct;
16(2):113-121.
PMID: 33117442
Cardiorenal syndrome (CRS) in people with type 2 diabetes mellitus (T2DM) illustrates the bidirectional link between the heart and the kidneys, with acute or chronic dysfunction of one organ adversely...
20.
Srinivasan B
FEBS J
. 2020 Sep;
288(7):2068-2083.
PMID: 32981225
Enzymology is concerned with the study of enzyme structure, function, regulation and kinetics. It is an interdisciplinary subject that can be treated as an exclusive sphere of exhaustive inquiry within...