Sam Tonddast-Navaei
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Explore the profile of Sam Tonddast-Navaei including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
88
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0
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Recent Articles
1.
Srinivasan B, Tonddast-Navaei S, Roy A, Zhou H, Skolnick J
Med Res Rev
. 2018 Sep;
39(2):684-705.
PMID: 30192413
Escherichia coli Dihydrofolate reductase is an important enzyme that is essential for the survival of the Gram-negative microorganism. Inhibitors designed against this enzyme have demonstrated application as antibiotics. However, either...
2.
Posgai M, Tonddast-Navaei S, Jayasinghe M, Ibrahim G, Stan G, Herr A
Proc Natl Acad Sci U S A
. 2018 Sep;
115(38):E8882-E8891.
PMID: 30181292
IgA effector functions include proinflammatory immune responses triggered upon clustering of the IgA-specific receptor, FcαRI, by IgA immune complexes. FcαRI binds to the IgA1-Fc domain (Fcα) at the C2-C3 junction...
3.
Srinivasan B, Rodrigues J, Tonddast-Navaei S, Shakhnovich E, Skolnick J
ACS Chem Biol
. 2018 Apr;
13(5):1407.
PMID: 29688000
No abstract available.
4.
Srinivasan B, Tonddast-Navaei S, Skolnick J
Bioorg Med Chem Lett
. 2017 Jul;
27(17):4133-4139.
PMID: 28739043
Traditional structure and ligand based virtual screening approaches rely on the availability of structural and ligand binding information. To overcome this limitation, hybrid approaches were developed that relied on extraction...
5.
Srinivasan B, Rodrigues J, Tonddast-Navaei S, Shakhnovich E, Skolnick J
ACS Chem Biol
. 2017 May;
12(7):1848-1857.
PMID: 28525268
In drug discovery, systematic variations of substituents on a common scaffold and bioisosteric replacements are often used to generate diversity and obtain molecules with better biological effects. However, this could...
6.
Tonddast-Navaei S, Srinivasan B, Skolnick J
J Comput Chem
. 2016 Nov;
38(15):1252-1259.
PMID: 27864975
Conventional small molecule drug-discovery approaches target protein pockets. However, the limited number of geometrically distinct pockets leads to widespread promiscuity and deleterious side-effects. Here, the idea of COmposite protein LIGands...
7.
Kravats A, Tonddast-Navaei S, Stan G
PLoS Comput Biol
. 2016 Jan;
12(1):e1004675.
PMID: 26734937
Clp ATPases are powerful ring shaped nanomachines which participate in the degradation pathway of the protein quality control system, coupling the energy from ATP hydrolysis to threading substrate proteins (SP)...
8.
Tonddast-Navaei S, Skolnick J
J Chem Phys
. 2016 Jan;
143(24):243149.
PMID: 26723634
Protein-protein interactions (PPIs) are involved in many cellular processes. Experimentally obtained protein quaternary structures provide the location of protein-protein interfaces, the surface region of a given protein that interacts with...
9.
Srinivasan B, Tonddast-Navaei S, Skolnick J
Eur J Med Chem
. 2015 Sep;
103:600-14.
PMID: 26414808
Gram-negative bacteria are implicated in the causation of life-threatening hospital-acquired infections. They acquire rapid resistance to multiple drugs and available antibiotics. Hence, there is the need to discover new antibacterial...
10.
Kravats A, Tonddast-Navaei S, Bucher R, Stan G
J Chem Phys
. 2013 Oct;
139(12):121921.
PMID: 24089733
Essential protein quality control includes mechanisms of substrate protein (SP) unfolding and translocation performed by powerful ring-shaped AAA+ (ATPases associated with various cellular activities) nanomachines. These SP remodeling actions are...