Micah J Niphakis
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Explore the profile of Micah J Niphakis including associated specialties, affiliations and a list of published articles.
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51
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1479
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Recent Articles
1.
Dixon C, Martin N, Niphakis M, Cravatt B, Fairn G
Cell Mol Gastroenterol Hepatol
. 2025 Mar;
:101491.
PMID: 40054525
Background And Aims: NOD2 is an intracellular innate immune receptor that detects bacterial peptidoglycan fragments. Although nominally soluble, some NOD2 is associated with the plasma membrane and endosomal compartments for...
2.
Niphakis M, Cravatt B
Cell Chem Biol
. 2024 Sep;
31(9):1636-1651.
PMID: 39303700
Genomic technologies have led to massive gains in our understanding of human gene function and disease relevance. Chemical biologists are a primary beneficiary of this information, which can guide the...
3.
League A, Yadav-Samudrala B, Kolagani R, Cline C, Jacobs I, Manke J, et al.
Front Immunol
. 2024 Jun;
15:1374301.
PMID: 38835765
Background: Human immunodeficiency virus (HIV) affects nearly 40 million people globally, with roughly 80% of all people living with HIV receiving antiretroviral therapy. Antiretroviral treatment suppresses viral load in peripheral...
4.
Yan S, Santoro A, Niphakis M, Pinto A, Jacobs C, Ahmad R, et al.
Nat Commun
. 2024 May;
15(1):4605.
PMID: 38816388
Obesity-induced inflammation causes metabolic dysfunction, but the mechanisms remain elusive. Here we show that the innate immune transcription factor interferon regulatory factor (IRF3) adversely affects glucose homeostasis through induction of...
5.
Dixon C, Martin N, Niphakis M, Cravatt B, Fairn G
bioRxiv
. 2024 Jan;
PMID: 38187608
Background And Aims: NOD2 is an intracellular innate immune receptor that detects bacterial peptidoglycan fragments. Although nominally soluble, some NOD2 is associated with the plasma membrane and endosomal compartments for...
6.
Keller L, Nguyen T, Liu L, Hurysz B, Lakemeyer M, Guerra M, et al.
Nat Chem Biol
. 2023 Jun;
19(12):1469-1479.
PMID: 37349583
Serine hydrolases have important roles in signaling and human metabolism, yet little is known about their functions in gut commensal bacteria. Using bioinformatics and chemoproteomics, we identify serine hydrolases in...
7.
Niphakis M, Cravatt B
Nat Chem Biol
. 2022 Jul;
18(11):1166-1167.
PMID: 35864330
No abstract available.
8.
Xu C, Yadav-Samudrala B, Xu C, Nath B, Mistry T, Jiang W, et al.
Cells
. 2022 Mar;
11(5).
PMID: 35269478
(1) Background. The endocannabinoid (eCB) system, which regulates physiological and cognitive processes, presents a promising therapeutic target for treating HIV-associated neurocognitive disorders (HAND). Here we examine whether upregulating eCB tone...
9.
League A, Gorman B, Hermes D, Johnson C, Jacobs I, Yadav-Samudrala B, et al.
Front Neurol
. 2021 Sep;
12:651272.
PMID: 34484091
While current therapeutic strategies for people living with human immunodeficiency virus type 1 (HIV-1) suppress virus replication peripherally, viral proteins such as transactivator of transcription (Tat) enter the central nervous...
10.
Onguka O, Babin B, Lakemeyer M, Foe I, Amara N, Terrell S, et al.
Cell Chem Biol
. 2021 May;
28(10):1501-1513.e5.
PMID: 34043961
The intracellular protozoan parasite Toxoplasma gondii must scavenge cholesterol and other lipids from the host to facilitate intracellular growth and replication. Enzymes responsible for neutral lipid synthesis have been identified...