Arthur Van Aerschot
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Explore the profile of Arthur Van Aerschot including associated specialties, affiliations and a list of published articles.
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Articles
106
Citations
894
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Recent Articles
1.
Vantieghem T, Aslam N, Osipov E, Akele M, Van Belle S, Beelen S, et al.
Eur J Med Chem
. 2024 Oct;
280:116960.
PMID: 39461037
Lens epithelium-derived growth factor p75 (LEDGF/p75), member of the hepatoma-derived growth-factor-related protein (HRP) family, is a transcriptional co-activator and involved in several pathologies including HIV infection and malignancies such as...
2.
Pang L, Lenders S, Osipov E, Weeks S, Rozenski J, Piller T, et al.
Int J Mol Sci
. 2022 Dec;
23(23).
PMID: 36499418
Mycothiol (MSH), the major cellular thiol in (Mtb), plays an essential role in the resistance of Mtb to various antibiotics and oxidative stresses. MshC catalyzes the ATP-dependent ligation of 1--(2-amino-2-deoxy-α-d-glucopyranosyl)-d--inositol...
3.
Pang L, Zanki V, Strelkov S, Van Aerschot A, Gruic-Sovulj I, Weeks S
Commun Biol
. 2022 Aug;
5(1):883.
PMID: 36038645
To correctly aminoacylate tRNA, leucyl-tRNA synthetase (LeuRS) catalyzes three reactions: activation of leucine by ATP to form leucyl-adenylate (Leu-AMP), transfer of this amino acid to tRNA and post-transfer editing of...
4.
Osipov E, Munawar A, Beelen S, Fearon D, Douangamath A, Wild C, et al.
RSC Chem Biol
. 2022 Aug;
3(8):1013-1027.
PMID: 35974998
Polyomaviruses are a family of ubiquitous double-stranded DNA viruses many of which are human pathogens. These include BK polyomavirus which causes severe urinary tract infection in immunocompromised patients and Merkel...
5.
Pang L, Weeks S, Juhas M, Strelkov S, Zitko J, Van Aerschot A
Int J Mol Sci
. 2021 Aug;
22(15).
PMID: 34360555
Human cytosolic prolyl-tRNA synthetase (HcProRS) catalyses the formation of the prolyl-tRNA, playing an important role in protein synthesis. Inhibition of HcProRS activity has been shown to have potential benefits in...
6.
Pang L, Weeks S, Van Aerschot A
Int J Mol Sci
. 2021 Feb;
22(4).
PMID: 33578647
Aminoacyl-tRNA synthetases (aaRSs) catalyze the esterification of tRNA with a cognate amino acid and are essential enzymes in all three kingdoms of life. Due to their important role in the...
7.
De Ruysscher D, Pang L, Lenders S, Cappoen D, Cos P, Rozenski J, et al.
Eur J Med Chem
. 2020 Nov;
211:113021.
PMID: 33248851
Leucyl-tRNA synthetase (LeuRS) is a clinically validated target for the development of antimicrobials. This enzyme catalyzes the formation of charged tRNA molecules, an essential substrate for protein translation. In the...
8.
Zhang B, Pang L, Nautiyal M, De Graef S, Gadakh B, Lescrinier E, et al.
Molecules
. 2020 Oct;
25(20).
PMID: 33081246
Aminoacyl-tRNA synthetases (aaRSs) have become viable targets for the development of antimicrobial agents due to their crucial role in protein translation. A series of six amino acids were coupled to...
9.
Gadakh B, Vondenhoff G, Pang L, Nautiyal M, De Graef S, Strelkov S, et al.
Bioorg Med Chem
. 2020 Aug;
28(17):115645.
PMID: 32773091
Despite of proven efficacy and well tolerability, albomycin is not used clinically due to scarcity of material. Several attempts have been made to increase the production of albomycin by chemical...
10.
De Ruysscher D, Pang L, Mattelaer C, Nautiyal M, De Graef S, Rozenski J, et al.
Bioorg Med Chem
. 2020 Jul;
28(15):115580.
PMID: 32631562
Antimicrobial resistance is considered as one of the major threats for the near future as the lack of effective treatments for various infections would cause more deaths than cancer by...