Anne F Mcgettrick
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Explore the profile of Anne F Mcgettrick including associated specialties, affiliations and a list of published articles.
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31
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2353
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Recent Articles
1.
Zotta A, Toller-Kawahisa J, Palsson-McDermott E, OCarroll S, Henry O, Day E, et al.
Sci Adv
. 2025 Jan;
11(4):eadq7307.
PMID: 39841829
The cytokine interleukin-10 (IL-10) limits the immune response and promotes resolution of acute inflammation. Because of its immunosuppressive effects, IL-10 up-regulation is a common feature of tumor progression and metastasis....
2.
OCarroll S, Peace C, Toller-Kawahisa J, Min Y, Hooftman A, Charki S, et al.
Nat Metab
. 2024 Dec;
7(1):228.
PMID: 39668260
No abstract available.
3.
OCarroll S, Peace C, Toller-Kawahisa J, Min Y, Hooftman A, Charki S, et al.
Nat Metab
. 2024 Oct;
6(11):2060-2069.
PMID: 39406969
Itaconate is one of the most highly upregulated metabolites in inflammatory macrophages and has been shown to have immunomodulatory properties. Here, we show that itaconate promotes type I interferon production...
4.
Bourner L, Chung L, Long H, Mcgettrick A, Xiao J, Roth K, et al.
Cell Rep
. 2024 Aug;
43(8):114570.
PMID: 39093697
A wide variety of electrophilic derivatives of itaconate, the Kreb's cycle-derived metabolite, are immunomodulatory, yet these derivatives have overlapping and sometimes contradictory activities. Therefore, we generated a genetic system to...
5.
Hooftman A, Peace C, Ryan D, Day E, Yang M, Mcgettrick A, et al.
Nature
. 2023 Mar;
615(7952):490-498.
PMID: 36890227
Metabolic rewiring underlies the effector functions of macrophages, but the mechanisms involved remain incompletely defined. Here, using unbiased metabolomics and stable isotope-assisted tracing, we show that an inflammatory aspartate-argininosuccinate shunt...
6.
Mcgettrick A, ONeill L
Curr Opin Immunol
. 2022 Nov;
80:102268.
PMID: 36446152
The metabolite itaconate (ITA) and its derivatives, both chemically synthesized and endogenous, have emerged as immunoregulators, with roles in limiting inflammation but also having effects on bacterial and viral infection....
7.
8.
Runtsch M, Angiari S, Hooftman A, Wadhwa R, Zhang Y, Zheng Y, et al.
Cell Metab
. 2022 Mar;
34(3):487-501.e8.
PMID: 35235776
The Krebs cycle-derived metabolite itaconate and its derivatives suppress the inflammatory response in pro-inflammatory "M1" macrophages. However, alternatively activated "M2" macrophages can take up itaconate. We therefore examined the effect...
9.
Diskin C, Corcoran S, Tyrrell V, Mcgettrick A, Zaslona Z, ODonnell V, et al.
J Immunol
. 2021 Oct;
207(10):2551-2560.
PMID: 34635586
The protozoan parasite is the causative agent of the neglected tropical disease human African trypanosomiasis, otherwise known as sleeping sickness. Trypanosomes have evolved many immune-evasion mechanisms to facilitate their own...
10.
Mcgettrick A, ONeill L
Cell Metab
. 2020 Aug;
32(4):524-536.
PMID: 32853548
HIF is a transcription factor that plays an essential role in the cellular response to low oxygen, orchestrating a metabolic switch that allows cells to survive in this environment. In...