Marah C Runtsch
Overview
Explore the profile of Marah C Runtsch including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
20
Citations
2154
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Zotta A, Toller-Kawahisa J, Palsson-McDermott E, OCarroll S, Henry O, Day E, et al.
Sci Adv
. 2025 Jan;
11(4):eadq7307.
PMID: 39841829
The cytokine interleukin-10 (IL-10) limits the immune response and promotes resolution of acute inflammation. Because of its immunosuppressive effects, IL-10 up-regulation is a common feature of tumor progression and metastasis....
2.
Cosic-Mujkanovic N, Valadez-Cosmes P, Maitz K, Lueger A, Mihalic Z, Runtsch M, et al.
Antioxidants (Basel)
. 2023 Aug;
12(8).
PMID: 37627581
Myeloperoxidase (MPO) is a neutrophil-derived enzyme that has been recently associated with tumour development. However, the mechanisms by which this enzyme exerts its functions remain unclear. In this study, we...
3.
Runtsch M, Angiari S, Hooftman A, Wadhwa R, Zhang Y, Zheng Y, et al.
Cell Metab
. 2022 Mar;
34(3):487-501.e8.
PMID: 35235776
The Krebs cycle-derived metabolite itaconate and its derivatives suppress the inflammatory response in pro-inflammatory "M1" macrophages. However, alternatively activated "M2" macrophages can take up itaconate. We therefore examined the effect...
4.
Huffaker T, Ekiz H, Barba C, Lee S, Runtsch M, Nelson M, et al.
Nat Commun
. 2021 May;
12(1):2620.
PMID: 33976173
Tumor associated macrophage responses are regulated by distinct metabolic states that affect their function. However, the ability of specific signals in the local tumor microenvironment to program macrophage metabolism remains...
5.
Runtsch M, Ferrara G, Angiari S
J Neurochem
. 2020 Sep;
158(1):36-58.
PMID: 32880969
Neuroinflammatory and neurodegenerative diseases are characterized by the recruitment of circulating blood-borne innate and adaptive immune cells into the central nervous system (CNS). These leukocytes sustain the detrimental response in...
6.
Hooftman A, Angiari S, Hester S, Corcoran S, Runtsch M, Ling C, et al.
Cell Metab
. 2020 Aug;
32(3):468-478.e7.
PMID: 32791101
The Krebs cycle-derived metabolite itaconate is highly upregulated in inflammatory macrophages and exerts immunomodulatory effects through cysteine modifications on target proteins. The NLRP3 inflammasome, which cleaves IL-1β, IL-18, and gasdermin...
7.
Runtsch M, ONeill L
Cell Metab
. 2020 Jun;
31(6):1045-1047.
PMID: 32492389
Itaconate is an immunometabolite with anti-inflammatory and anti-microbial properties. Riquelme et al. (2020) demonstrate that pathogenic Pseudomonas aeruginosa drives itaconate production by macrophages, which it then uses as a carbon...
8.
Angiari S, Runtsch M, Sutton C, Palsson-McDermott E, Kelly B, Rana N, et al.
Cell Metab
. 2019 Nov;
31(2):391-405.e8.
PMID: 31761564
Pyruvate kinase (PK) catalyzes the conversion of phosphoenolpyruvate to pyruvate during glycolysis. The PK isoform PKM2 has additional roles in regulation of gene transcription and protein phosphorylation. PKM2 has been...
9.
Hughes M, Hooftman A, Angiari S, Tummala P, Zaslona Z, Runtsch M, et al.
Cell Rep
. 2019 Oct;
29(1):151-161.e5.
PMID: 31577945
The NLRP3 inflammasome is a cytosolic complex sensing phagocytosed material and various damage-associated molecular patterns, triggering production of the pro-inflammatory cytokines interleukin-1 beta (IL)-1β and IL-18 and promoting pyroptosis. Here,...
10.
Runtsch M, Nelson M, Lee S, Voth W, Alexander M, Hu R, et al.
PLoS Genet
. 2019 Feb;
15(2):e1007970.
PMID: 30768595
Identifying regulatory mechanisms that influence inflammation in metabolic tissues is critical for developing novel metabolic disease treatments. Here, we investigated the role of microRNA-146a (miR-146a) during diet-induced obesity in mice....